Postdoc: Single-Cell Multi-Omics in Autoimmune Rheumatology

Imagine - Institut des maladies génétiques; Paris; Vor Ort; EUR 42.000 - 65.000; Vollzeit

Benefits dieser Stelle

Competitive salary

Access to clinical cohorts

Career development opportunities

Live in Paris

Zusammenfassung

Imagine - Institut des maladies génétiques in Paris invites applications for a postdoctoral researcher to join the SMART-JIA project validating predictive biomarkers of anti-TNF non-response in JIA and adult RA. The role focuses on single-cell multi-omics, functional assays, and AI-driven stratification tools, with close collaboration to pediatric and adult rheumatology centers.

The successful candidate will work with primary human immune cells, integrate molecular data with clinical cohorts,

Qualifikationen

• PhD in Immunology, Cell Biology, Molecular Biology, or a related discipline.
• Excellent scientific communication skills (written and oral, in English).
• Ability to work independently in a collaborative, translational research environment.

Aufgaben

• Design, perform, and analyze single-cell multi-omics experiments (10x Genomics Multiome, scRNA-seq, scATAC-seq) from patient-derived PBMCs.
• Develop and execute ex vivo functional assays to investigate molecular mechanisms of treatment resistance.
• Perform computational analyses of single-cell datasets or collaborate with bioinformaticians.
• Contribute to biomarker validation and development of the SMART-Score predictive algorithm with clinical collaborators.

Kenntnisse

Sci. communication

Independent work

Translational research

Ausbildung

PhD in Immunology

Tools

10x Genomics

Jobbeschreibung

Imagine - Institut des maladies génétiques in Paris invites applications for a postdoctoral researcher to join the SMART-JIA project validating predictive biomarkers of anti-TNF non-response in JIA and adult RA. The role focuses on single-cell multi-omics, functional assays, and AI-driven stratification tools, with close collaboration to pediatric and adult rheumatology centers.

The successful candidate will work with primary human immune cells, integrate molecular data with clinical cohorts,