Postdoc: Mitochondrial Nucleic Acid Immunity in CNS

Imagine - Institut des maladies génétiques; Paris; Sur place; EUR 42 000 - 54 000; Plein temps

Résumé du poste

Imagine - Institut des maladies génétiques in Paris invites applications for a one-year postdoctoral position in the team of Dr Alice Lepelley to study mitochondrial nucleic acid immunogenicity and neuroinflammation in genetic diseases.

The project will use patient-derived cells, iPSC models, CRISPR/Cas9 gene editing, advanced fluorescence microscopy and transcriptomic analyses to understand how mitochondrial nucleic acids trigger innate immune responses in the CNS.

Qualifications

• PhD in a relevant field.
• Solid experience in molecular and cellular biology and mitochondrial studies.
• Experience with iPSC culture and differentiation into neural cells.
• Fluent in English; ability to communicate with international collaborators.
• Ability to work independently and lead the project.

Responsabilités

• Study mechanisms controlling mitochondrial nucleic acid immunogenicity in disease contexts.
• Employ patient-derived cells, iPSC-derived CNS models, and advanced imaging.
• Collaborate with team and external partners and contribute to scientific reporting.

Connaissances

Molecular biology

Cell biology

Mitochondrial studies

iPSC culture and neural diff.

Fluent English

Formation

PhD in a relevant field

Outils

CRISPR/Cas9

Advanced fluorescence microscopy

Nanopore sequencing

PacBio sequencing

Description du poste

Imagine - Institut des maladies génétiques in Paris invites applications for a one-year postdoctoral position in the team of Dr Alice Lepelley to study mitochondrial nucleic acid immunogenicity and neuroinflammation in genetic diseases.

The project will use patient-derived cells, iPSC models, CRISPR/Cas9 gene editing, advanced fluorescence microscopy and transcriptomic analyses to understand how mitochondrial nucleic acids trigger innate immune responses in the CNS.