Postdoc: MSA Pathogenesis & α-Syn Fibrils

Bordeaux Neurocampus

Bordeaux

Sur place

EUR 36 000 - 48 000

Plein temps

14 jours+

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Résumé du poste

Bordeaux Neurocampus seeks an independent postdoctoral scientist to investigate the molecular and cellular pathogenesis of Multiple System Atrophy (MSA) within the SynTeam. The project, funded for a Franco-Swiss collaboration, aims to dissect how α-synuclein fibrils drive disease in mice and cellular models using advanced imaging and CLEM.

The candidate will seed α-syn fibrils, study their progression, and identify factors that modulate the 1B polymorph to prevent propagation.

Qualifications

PhD required with strong background in molecular neuroscience and experimental neuropathology.
Experience with in vivo experimentation including stereotaxic surgery is required.
Brain immunohistology and imaging techniques are advantageous.
Excellent communication skills in English; French not mandatory.

Responsabilités

Study the pathogenesis of MSA using the 1B fibril polymorph in primary cell cultures and in vivo models.
Investigate fibril origins, cellular environment, and protein interactions to understand propagation mechanisms.
Seed fibrils in vivo and in vitro, analyze structure and binding proteins, and assess invasion into neuronal compartments.
Identify strategies to prevent fibril propagation and modulate the 1B fold.
Collaborate in Franco-Swiss research efforts and contribute to publications.