POSTDOC_065_MK - H/F

Inserm France; Illkirch-Graffenstaden; Hybride; EUR 32 000 - 42 000; Plein temps

Résumé du poste

Inserm France in Illkirch-Graffenstaden invites a student to join our lab studying myotendinous junction translation programs. You will use mouse genetics to generate mutants, analyze phenotypes, and explore the local translatome.

The project includes biochemical pull-downs, mass spectrometry and NGS, plus presenting results at lab meetings and conferences and supervising Master's students. English language required.

Qualifications

• Mouse genetics maintenance, genotyping, histological analyses and imaging.
• Physiological tests for phenotyping muscle function.
• Biochemical skills for mass spectrometry and NGS.

Responsabilités

• Use mouse genetics to generate mutants and dissect their phenotype.
• Investigate the local translatome upon mutating RNA binding proteins and identify their binding partners.
• Biochemical pull-down identification of candidate factors using affinity tag fused UTRs.
• Presentation of the work in lab meetings and conferences.
• Supervising Master students.

Connaissances

Mouse genetics

Physiological tests

Biochemical skills

Formation

Master's degree

Outils

Mass spectrometry

NGS

Description du poste

About the position

Myotendinous junction (MTJ) is a mechanical buffer of the skeletal muscle cell and prone site to injury upon exercise. Our lab recently developed a new tool to manipulate the MTJ domain and revealed its local translational program as well as how it rewires after exercise. However, the molecular mechanism by which this special translation program is achieved remains unknown. The student will take both candidate and unbiased approaches to address this problem.

• Use mouse genetics to generate mutants of candidate RNA binding proteins and dissect their phenotype.
• Investigate the local translatome upon mutating RNA binding proteins and identify their binding partners.
• Biochemical pull-down identification of candidate factors using affinity tag fused UTRs
• Presentation of the work in lab meetings and conferences.
• Supervising Master students.

Desired profile

Specific Requirements or Constraints :

• Mouse genetics skills: maintenance, genotyping, histological analyses, and imaging
• Physiological tests: various assays for phenotyping muscle function
• Biochemical skills for mass-spectrometry, NGS etc.

Skills/Qualifications :

• Communication skills (presentation, writing)
• Collaborative team spirit

Fields : Biological Science.

Required Languages : english.

Application requirements

Required document(s)

Offer info

Published on 09/15/2026 Contractuel Catégorie A Fixed-term contract - 36 months Full time Beginner accepted License not required Master degree level Master.