POSTDOC_066_IS - H/F

Inserm France; Illkirch-Graffenstaden; Hybrid; EUR 32,000 - 42,000; Full time

Job summary

Inserm France is seeking a highly motivated researcher to join the Functional Genomics and Cancer Department at IGBMC, working on mechanisms controlling nuclear pore complex assembly in health and disease.

Under supervision of team leader Izabela Sumara, you will apply cell biology, advanced microscopy and biochemical approaches and actively communicate findings.

This fixed-term contract (12 months) requires a PhD in biological sciences and fluency in English.

Qualifications

• PhD in biological sciences or a closely related field.
• Strong background in cell biology and biochemistry.
• Experience with advanced microscopy techniques.

Responsibilities

• Investigate mechanisms of NPC assembly in healthy and diseased cells.
• Combine cell biology, advanced microscopy, and biochemical approaches.
• Communicate research findings within the laboratory and institute.

Skills

Cell biology

Advanced microscopy

Biochemical approaches

Education

PhD in biological sciences

Master's degree

Job description

About the position

The successful candidate will join the team within the Functional Genomics and Cancer Department at IGBMC, which investigates the signaling pathways responsible for the assembly of nuclear pore complexes during the cell cycle in both healthy and diseased cells. They will work under the direct supervision of the team leader, Izabela Sumara.

• The successful candidate will investigate the mechanisms governing nuclear pore complex (NPC) assembly in healthy and diseased cells.
• Scientific project and responsibilities:
  Neurological diseases represent a major medical challenge, causing 6.8 million deaths annually and constituting one of the leading sources of disability worldwide. Despite decades of research, the vast majority of these conditions remain without curative treatment, underscoring the urgent need to identify novel therapeutic targets. The nuclear pore complex (NPC), the sole gateway between the nucleus and the cytoplasm, ensures the nucleocytoplasmic transport essential for neuronal survival and function. Alterations in nucleoporin (Nup) assembly and nucleocytoplasmic transport have recently been identified as a shared pathological hallmark of several severe neurological diseases, opening an unprecedented therapeutic avenue. This project aims to validate the therapeutic potential of a gene therapy strategy targeting NPC homeostasis in human disease.
• The successful candidate will investigate the mechanisms of NPC assembly in healthy and diseased cells by combining cell biology, advanced microscopy, and biochemical approaches.
• The successful candidate will actively communicate their research findings within the laboratory and the institute.

Desired profile

The successful candidate will investigate the mechanisms of NPC assembly in healthy and diseased cellsby combining cell biology, advanced microscopy, and biochemical approaches.

Research field : biological sciences.

Required language : english.

Application requirements

Required document(s)

Offer info

Published on 09/22/2026 Contractuel Catégorie A Fixed-term contract - 12 months Full time Experience preferred License not required > Master degree level PhD.