PhD Position in Organic Synthesis/Glycochemistry – SILYSUGAR | Université de Poitiers

Biopractify; Poitiers; Hybrid; EUR 24,000 - 30,000; Full time

Job summary

Biopractify seeks a PhD researcher in Organic Synthesis/Glycochemistry to work on SILYSUGAR project at IC2MP, Université de Poitiers. You will develop multi-step routes toward novel iminosugar glycomimetics, study conformational properties, and evaluate glycosidase inhibition in collaboration with partners.

The role combines synthetic chemistry with biological evaluation, offering hands-on training in modern organic synthesis, glycochemistry, and structure–activity relationships at the

Qualifications

• Strong background in organic chemistry.
• ,
• Experience with multi-step organic synthesis.
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• Practical experience from M1/M2 internships or equivalent research.
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• Purification of organic compounds.

Responsibilities

• Develop and optimize multi-step synthetic routes toward novel iminosugar glycomimetics.
• Synthesize and modify carbohydrate-derived molecules.
• Handle and optimize synthetic intermediates.
• Purify and characterize compounds using HPLC, MS, IR, NMR.

Skills

Organic chemistry

Multi-step synthesis

Conformational analysis

Glycochemistry

Glycomimetics

Silyl nitronates

M1/M2 internship

Tools

NMR

MS

IR

HPLC

Silica chromatography

Job description

Research Group: Glycochemistry Group – Organic Synthesis

Project: SILYSUGAR – Harnessing the Ambiphilicity of Silyl Nitronates to Boost Aglycon Structural Diversity in Glycomimetics

Research Areas: Organic Chemistry | Glycochemistry | Glycomimetics | Organic Synthesis | Medicinal Chemistry | Chemistry-Biology Interface

The IC2MP at Université de Poitiers, in collaboration with the CNRS, is offering a PhD position in Organic Synthesis/Glycochemistry as part of the SILYSUGAR (ANR) project.

The project focuses on developing new synthetic strategies for C1-functionalized iminosugar glycomimetics by exploiting the ambiphilicity of silyl nitronates. The research aims to expand the structural diversity of glycomimetics and investigate their potential biological properties.

The successful candidate will work on the development of innovative synthetic approaches for C1-functionalized iminosugars and their biological evaluation.

The research will involve:

• Development of multi-step organic synthesis strategies.
• Synthesis of nitromethyl iminosugars.
• Functionalization of iminosugar scaffolds.
• Exploitation of the ambiphilicity of silyl nitronates.
• Structural and conformational analysis of synthesized molecules.
• Evaluation of glycosidase inhibition in collaboration with project partners.
• Investigation of structure–activity relationships at the chemistry-biology interface.

The project combines synthetic organic chemistry, glycochemistry, conformational analysis, and biological evaluation.

What You’ll Work On

The PhD researcher will develop and optimize multi-step synthetic routes toward novel iminosugar glycomimetics.

Key activities will include:

• Reaction design and optimization.
• Multi-step synthesis.
• Synthesis and modification of carbohydrate-derived molecules.
• Handling and optimization of synthetic intermediates.

The candidate will be responsible for purification and characterization of synthesized compounds using techniques such as:

• HPLC purification.
• Mass spectrometry (MS).
• Infrared spectroscopy (IR).
• Other standard organic chemistry characterization techniques.

The project will investigate the conformational properties of synthesized glycomimetics to understand how molecular structure influences their biological properties.

Selected compounds will be evaluated for their ability to interact with and inhibit glycosidase enzymes, in collaboration with research partners.

The research will connect synthetic chemistry with biological evaluation to investigate the potential of newly developed iminosugar glycomimetics.

Applicants should have a strong academic background in organic chemistry and practical laboratory experience.

Candidates should possess:

• A solid background in organic chemistry.
• Experience with multi-step organic synthesis.
• Practical experience obtained during an M1/M2 internship or equivalent research project.
• Experience with purification of organic compounds.
• Experience with silica-gel chromatography and/or HPLC.
• Experience with characterization techniques such as NMR, MS, and IR.
• Strong motivation for research in synthetic chemistry.
• Interest in the chemistry-biology interface.
• Ability to work independently and as part of a collaborative research team.
• Organic synthesis.
• Multi-step synthesis.
• Purification of organic compounds.
• Spectroscopic characterization.
• Mass spectrometry.
• Experience in glycochemistry.
• Knowledge of iminosugars or glycomimetics.
• Experience with conformational analysis.
• Interest or experience in medicinal chemistry.
• Familiarity with enzyme inhibition studies.

Note: Previous glycochemistry experience is an advantage but not mandatory.

What You’ll Gain

• Advanced training in modern organic synthesis.
• Hands-on experience in glycochemistry and glycomimetics.
• Training in purification and advanced molecular characterization.
• Exposure to conformational analysis.
• Experience investigating glycosidase inhibition.
• Opportunity to work at the interface of chemistry and biology.
• Collaboration with academic research partners.
• Experience within an interdisciplinary international research environment.

Position: PhD Researcher

Project: SILYSUGAR – Harnessing the Ambiphilicity of Silyl Nitronates to Boost Aglycon Structural Diversity in Glycomimetics

Funding: ANR

Research Group: Glycochemistry Group

Research Focus: Organic Synthesis | Glycochemistry | Glycomimetics

Academic Background: Strong background in Organic Chemistry

Experience: M1/M2 internship or equivalent practical research experience

Required Skills: Multi-Step Synthesis | Purification | Silica Chromatography | HPLC | NMR | MS | IR

Preferred Knowledge: Glycochemistry | Glycomimetics | Conformational Analysis

Personal Qualities: Motivation | Teamwork | Research Interest | Chemistry-Biology Interface

Glycochemistry Experience: Advantage, but not mandatory

Research Institute: IC2MP

Research Group: Glycochemistry Group

Position: PhD Researcher

Project: SILYSUGAR

Funding: ANR

Research Area: Organic Synthesis | Glycochemistry | Glycomimetics

Research Topics: Silyl Nitronates | Iminosugars | Nitromethyl Iminosugars | Conformational Analysis | Glycosidase Inhibition

Required Background: Organic Chemistry

Required Experience: Multi-Step Synthesis | Purification | Characterization

Desirable: Glycochemistry Experience

Application Documents: CV | Cover Letter | Two Academic Referees

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