PhD opportunity - Modulating X chromosome gene dosage and senescence induction

CNRS - CBI-Toulouse; France; On-site; EUR 21,000 - 27,000; Full time

Job summary

The CNRS - CBI-Toulouse invites applications for a PhD candidate position in Toulouse, France, as part of BEST Doctoral Programme. The project focuses on Modulating X chromosome gene dosage and senescence induction, supervised by Estelle Nicolas in the Developmental Regulation of Gene Dosage team.

The PhD candidate will spend 6 months collaborating with the Stem Cell Epigenetics Lab in Lisbon, Portugal, training in human embryonic stem cell manipulation and returning to Toulouse to complete the

Qualifications

• PhD candidate status with admission to BEST Doctoral Programme.
• Experience in biology laboratory work is desirable.

Responsibilities

• Conduct research on modulating X chromosome gene dosage and senescence induction.
• Collaborate with Stem Cell Epigenetics Lab in Lisbon for a 6-month training period.

Education

PhD student in progress

Job description

Organisation/Company CNRS - CBI-Toulouse Department Biology Research Field Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Positions PhD Positions Application Deadline 23 Oct 2026 - 10:00 (UTC) Country France Type of Contract Permanent Job Status Full-time Is the job funded through the EU Research Framework Programme? Horizon Europe – COFUND Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The CBI (Centre for Integrative Biology) is seeking motivated PhDcandidatesas part of the BEST DoctoralProgramme of the University of Toulouse.Located in Toulouse, in France, the CBI is a a fundamental biology research institute affiliated with the National Center for Scientific Research (CNRS) – the largest public research organization in France – and the University of Toulouse.

The CBI aims to understand the mechanisms, dynamics and behaviors of living organisms, to advance knowledge on the current societal challenges. Research at the CBI use multidisciplinary and multi-scale approaches, from isolated molecules to whole organisms and animal societies, applied to numerous model organisms, from bacteria to animal models and to humans.

This PhD opportunity is entitled : Modulating X chromosome gene
dosage and senescence induction

The project will be primarily conducted at the Center of Integrative Biology (CBI) in Toulouse (France) under the supervision of Estelle Nicolas from the Developmental Regulation of Gene Dosage team , which provides the laboratory infrastructure, equipment and expertise required for the feasibility of the PhD project, including cell culture, molecular and cellular biology, genomics bioengineering, bioinformatics and microscopy. This PhD project includes an international collaboration with the Stem Cell Epigenetics Lab (Lisbon, Portugal), led by S.T. Da Rocha, where the PhD candidate will spend 6 months to be trained on the use and genetic manipulation of human embryonic stem cells, transferring this knowledge back to Toulouse.