PhD position in cryo-EM: Structural and Mechanistic Basis of TIP60 Complex Function in Chromatin Regulation and Genome Integrity

Institute of Genetics and Molecular and Cellular Biology; France; Sur place; EUR 23 000 - 28 000; Plein temps

Résumé du poste

Institute of Genetics and Molecular and Cellular Biology in France invites applications for a PhD position to study the structural and mechanistic basis of TIP60 Complex function in chromatin regulation and genome integrity. The project integrates cryo-EM, biochemistry, cell biology, and computational drug discovery.

The successful candidate will join an international team and access state-of-the-art facilities and a three-year contract with potential fourth-year extension, starting 1 Dec 2026.

Qualifications

• Master's degree (or near completion) in a related field.
• Background in protein biochemistry or structural biology is a plus.
• Interest in interdisciplinary approaches and collaboration.

Responsabilités

• Engage in structural biology, biochemistry, cell biology and computational drug discovery.
• Perform cryo-EM studies and structure-based drug lead design.
• Collaborate in an international research environment to advance TIP60-C understanding.

Connaissances

Motivation and interest in structural

Strong communication

Collaborative spirit

Formation

Master's degree in biochemistry/chemistry/molecular biology/biomedical sciences

Description du poste

Institute of Genetics and Molecular and Cellular Biology

Organisation/Company Institute of Genetics and Molecular and Cellular Biology Department Integrated Structural biology Research Field Chemistry » Biochemistry Biological sciences » Biology Medical sciences » Cancer research Researcher Profile First Stage Researcher (R1) Positions PhD Positions Application Deadline 15 Oct 2026 - 09:30 (Europe/Luxembourg) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 38 Offer Starting Date 1 Dec 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

PhD position:Structural and Mechanistic Basis of TIP60 Complex Function in Chromatin Regulation and Genome Integrity

Background

TheTIP60/EP400 complex (TIP60-C)is a highly conserved 20-subunit chromatin remodeling complex that plays fundamental roles in gene transcription and the maintenance of genome integrity. Through its lysine acetyltransferase (KAT) activity, TIP60-C acetylates histones H4 and H2A to promote chromatin relaxation, while its EP400 ATPase subunit catalyzes the exchange of canonical H2A for the histone variant H2A.Z, thereby regulating chromatin dynamics during transcription and DNA damage repair.

Beyond chromatin regulation, TIP60-C acts as a central signaling hub that coordinates diverse cellular processes, including DNA repair, immune responses, cell cycle progression, apoptosis, autophagy, metabolism, and development. These functions are mediated through the acetylation of both histone and non-histone substrates, which modulates protein activity, stability, and molecular interactions. Dysregulation of TIP60-C is implicated in numerous human diseases, including cancer, neurodegenerative disorders, and viral infections, making it a compelling therapeutic target.

Our laboratory recently solved the high-resolution cryo-EM structure of the endogenous human TIP60 complex ( https://www.nature.com/articles/s41586-024-08011-w ), providing an unprecedented view of its molecular architecture. This PhD position builds directly on that breakthrough.

Project Aims

• Determine how TIP60-C recognizes nucleosomes to drive H2A.Z exchange.
• Elucidate the molecular mechanisms by which TIP60-C promotes DNA damage repair.
• Identify and develop novel therapeutic modulators of TIP60-C.

Approach

The project integrates structural biology, biochemistry, cell biology, and computational drug discovery. The successful candidate will employ an interdisciplinary approach, combining single-particle cryo-electron microscopy, structure-based virtual screening, AI-driven de novo peptide and mini-protein design, biochemical characterization, and cellular functional assays.

Candidate Profile

• Highly motivated, with a strong interest in structural biology and biochemistry
• Master's degree (or near completion) in biochemistry, chemistry, molecular biology, biomedical sciences, or a related field.
• Prior experience in protein biochemistry, structural biology, computational biology, or cell biology is a plus, but not required.
• Strong communication skills, intellectual curiosity, and the ability to thrive in a collaborative, international research environment.

What We Offer

• Access to state-of-the-art cryo-EM facilities and cutting-edge computational infrastructure.
• Membership in a dynamic, international team at IGBMC working at the interface of structural biology and structure-based drug leads design.
• A three years’ contract (fourth-year extension possible, subject to competitive funding), salary approximately €2,300 gross/month.