PhD Fellowship: Early Large Subunit Ribosome Assembly in Yeast

Cnrs Inc; France; Presencial; EUR 21.000 - 27.000; Jornada completa

Descripción de la vacante

The CNRS – Unité de biologie moléculaire, cellulaire et du développement invites applications for a PhD student to study early assembly and maturation of pre-ribosomal particles in yeast Saccharomyces cerevisiae. You will join a team of over 200 people across four programmes, focusing on ribosome synthesis and the Npa1 complex with snoRNPs and AFs.

The project uses quantitative mass spectrometry, SHAPEmap, nanopore RNA sequencing and cryo-ME to unravel molecular mechanisms, with extensions to

Formación

• PhD in life sciences required.
• Experience with yeast Saccharomyces cerevisiae is advantageous.
• Strong background in ribosome biology and RNA processing.

Responsabilidades

• Unravel early stages of large subunit synthesis in pre-ribosomal particles.
• Apply quantitative mass spectrometry and SHAPEmap to map assembly steps.
• Use nanopore sequencing and cryo-EM to study molecular machinery, with cross-species comparisons.

Conocimientos

Molecular biology

Ribosome biogenesis

Mass spectrometry

Cryo-EM

RNA biology

Educación

PhD in life sciences

Yeast genetics

Herramientas

SHAPEmap

Nanopore sequencing

Cryo-EM

Descripción del empleo

The CNRS – Unité de biologie moléculaire, cellulaire et du développement invites applications for a PhD student to study early assembly and maturation of pre-ribosomal particles in yeast Saccharomyces cerevisiae. You will join a team of over 200 people across four programmes, focusing on ribosome synthesis and the Npa1 complex with snoRNPs and AFs.

The project uses quantitative mass spectrometry, SHAPEmap, nanopore RNA sequencing and cryo-ME to unravel molecular mechanisms, with extensions to