Research Engineer: tRNA Synthesis for NMR & Cell-Free Tech

Institut de Biologie Structurale; France; On-site; EUR 35,000 - 38,000; Full time

Benefits offered by this job

Public transport subsidy

Mobility allowance

Annual leave 44 days

Job summary

Institut de Biologie Structurale in Grenoble, France seeks a highly motivated research engineer to join the NMR of Large Assemblies (NMRLA) group. You will contribute to cutting-edge structural biology research by developing and optimizing tRNA production for advanced cell-free and biomolecular NMR applications.

The role involves setting up large-scale production, designing molecular biology protocols, and developing purification workflows in an RNase-free environment.

Qualifications

• Master's degree or engineering diploma in biochemistry, chemistry, biological engineering or molecular biology, plus two years of research experience in RNA (preferably tRNA) biochemistry, or a PhD in RNA biochemistry.
• Fluent English (level B2 or higher) is required.
• Knowledge of NMR is not a prerequisite.
• Ability to conceptualize, creativity, scientific curiosity, and a sense of innovation.

Responsibilities

• Be responsible for setting up efficient large-scale in vitro and in vivo production of multiple tRNAs.
• Design molecular biology and enzymology techniques to produce homogeneous, functional tRNAs.
• Develop and optimise protocols to purify tRNAs on a large scale using FPLC chromatography under native conditions.
• Work in a dedicated RNase-free environment to ensure the highest quality RNA production.

Skills

RNA biochemistry

tRNA production

Molecular biology

Enzymology

Education

Master's degree in biochemistry/engineering

PhD in RNA biochemistry

Tools

FPLC chromatography

RNA purification techniques

Job description

Institut de Biologie Structurale in Grenoble, France seeks a highly motivated research engineer to join the NMR of Large Assemblies (NMRLA) group. You will contribute to cutting-edge structural biology research by developing and optimizing tRNA production for advanced cell-free and biomolecular NMR applications.

The role involves setting up large-scale production, designing molecular biology protocols, and developing purification workflows in an RNase-free environment.