Bioinformatician position in cancer research (F/M)

Institut Curie; Paris; Hybrid; EUR 55,000 - 75,000; Full time

Job summary

Institut Curie invites a PhD-trained bioinformatician to join the ARTURO project team. The role focuses on analyzing transcriptomics data including bulk RNA-seq, deconvolution, scRNA-seq and Visium spatial data, in close collaboration with experimental scientists to interpret findings.

You will participate in ongoing monitoring, data interpretation, and dissemination through reports and publications, contributing to cutting-edge cancer research in a multinational setting.

Qualifications

• PhD in bioinformatics, computational biology, or a closely related field; strong background in transcriptomics.
• PhD with experience in cancer biology is an advantage.
• Proven experience in analyzing bulk and single-cell sequencing data.

Responsibilities

• Perform bioinformatics analyses of transcriptomics data (bulk RNA-seq, deconvolution, scRNA-seq, Visium).
• Collaborate daily with experimental scientists to interpret data.
• Maintain scientific and technological monitoring relevant to ARTURO project.
• Present results in meetings and prepare reports and publications.

Skills

RNA-seq analysis

Single-cell RNA-seq

Spatial transcriptomics

Biostatistics

Bioinformatics

Education

PhD in bioinformatics/genomics

Tools

R

Python

Seurat

Bioconductor

Job description

Laboratory

"Chemical Biology of Cancer" Unit - Director: Fatima Mechta-Grigoriou

Institut Curie - U1339 Inserm - UMR3666 CNRS

“Stress and Cancer” Laboratory - Director: Fatima Mechta-Grigoriou

https://curie.fr/equipe/mechta-grigoriou

This position is associated with the ARTURO project, funded by the European Commission under the Horizon Europe programme (Cancer Mission 2023).

International collaboration between Institut Curie and Assistance Publique Hôpitaux de Paris - Bichat hospital (France), Universidade Catolica Portugueasa and Fundação Gaspar Frutuoso (Portugal), University of Rome TorVergata and Humanitas University in Milan (Italy).

Coordinated by Dr Maria Carla Parrini.

https://www.arturoproject.eu

Therapy resistance remains a major challenge in oncology. Recent studies suggest that the intratumoral microbiome influences responses to anticancer treatments, particularly immunotherapy. The ARTURO project aims to better understand the role of bacteria and their metabolites in the tumor microenvironment and in drug response through an innovative 3D tumor-on-chip model integrating clinical data, multi-omics analyses, and state-of-the-art technologies. The research focuses on non-small cell lung cancer and invasive lobular breast cancer.

Missions

• Perform bioinformatics analyses of transcriptomics data (bulk RNA‑seq, deconvolution, scRNA‑seq, and Visium HD spatial transcriptomics).
• Interact on a daily basis with experimental scientists generating the data.
• Conduct scientific and technological monitoring relevant to the project.
• Communicate analysis results through meetings, written reports, and scientific publications.