Bioinformaticien – Ingénieur (F/H)

Institut Curie; Paris; Hybrid; EUR 40,000 - 70,000; Full time

Job summary

Institut Curie in Paris is seeking a motivated bioinformatician to join the Genomics and Development of Childhood Cancers lab, focusing on cancer and single-cell genomics. The project involves multi-omics characterization of tissues and tumors using single-cell and spatial approaches.

You will work in a highly collaborative, international environment with access to cutting-edge platforms and datasets, contributing to understanding developmental origins of pediatric brain cancers.

Qualifications

• PhD or equivalent in bioinformatics, computational biology, or a related field.
• Experience in analyzing cancer genomics and single-cell datasets is preferred.
• Strong programming and data-visualisation skills.

Responsibilities

• Perform multi-omics data integration and analyses for pediatric cancer projects.
• Develop and apply single-cell and spatial genomics workflows.

Skills

Bioinformatics

Single-cell genomics

Cancer genomics

Education

PhD in bioinformatics or computational biology

Tools

R

Python

Spatial transcriptomics

Job description

Laboratories

The Genomics and Development of Childhood Cancers lab (https://institut-curie.org/team/saulnier), headed by Dr. Olivier Saulnier is looking for a motivated bioinformatician on cancer/single-cell genomics.

We are located in the heart of Paris at Institut Curie, one of the world's leading institutions in cancer research. It represents an excellent and international environment with interdisciplinary expertise and high-quality technological platforms.

Missions

Our lab aims to better understand the development origins of childhood brain cancers. The project will involve multi-omics characterization of human fetal tissue and childhood brain tumors using single-cell and spatial approaches.

Key publications

1/ Saulnier*, Zagozewski*, Liang*, Hendrikse*, et al., A Group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing. Nature Cell Biology. 2024

2/ Visvanathan*, Saulnier*, Chuan*, et al., Early Rhombic Lip Protogenin+ve Stem Cells in a Human Specific Neurovascular Niche Initiate and Maintain Group 3 Medulloblastoma. Cell 2024

3/ Hendrikse*, Haldipur*, Saulnier*, et al., Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. 2022