Scientist: Bioconjugation and Diagnostic Assay Development (m/w/d)

乡湯条浩; München; Vor Ort; EUR 60.000 - 80.000; Vollzeit

Zusammenfassung

A leading biotech startup specializing in DNA Origami-based nanotechnology is seeking a Bioconjugation & Diagnostics Assay Development Scientist. This role involves developing novel protein bioconjugation strategies and optimizing assay technologies, contributing significantly to the future of diagnostics and personalized medicine. The candidate will collaborate with a multidisciplinary team and operate in a dynamic startup environment.

Leistungen

Accelerated career trajectory

Competitive compensation

Flexible working models

International work culture

State-of-the-art technology package

Qualifikationen

• Extensive expertise in bioconjugation of proteins, particularly antibodies.
• Proficiency in protein assays and purification techniques.
• Excellent interpersonal and communication skills.

Aufgaben

• Independently develop and optimize protein bioconjugation strategies.
• Set up systems for purification, characterization and functional assays.
• Collaborate with scientists and engineers to optimize biochip performance.

Kenntnisse

Bioconjugation

Protein Characterization

Communication

Ausbildung

Ph.D. in Chemistry, Biochemistry, or related field

Tools

Affinity Chromatography

Western Blots

IE-HPLC

Jobbeschreibung

Nanogami is a highly innovative and rapidly growing startup in the field of DNA Origami-based nanotechnology (check out our DLD Talk or this article to learn more). Our international team is driven by a shared vision: to pioneer a novel generation of biochips set to unlock applications in research and diagnostics and thereby pushing the boundaries of personalised medicine to new heights. We recently secured significant funding by SPRIND - Germany's Federal Agency for Disruptive Innovation to realize our ambitious growth trajectory and now aim to significantly expand our current team to support the at-scale commercialisation of our nanotechnology.

Join us as Bioconjugation & Diagnostics Assay Development Scientist (m/w/d) to help shape the future of proteomics.

You will be working in cross-functional teams to develop and optimize protein bioconjugation and DNA origami surface immobilization strategies. You'll own your experiments end-to-end, using covalent binding methods and biophysical tools like AFM, optical microscopy, and mass photometry to analyze and refine your work.

Your Role:

• Independently develop and optimize protein bioconjugation strategies, with a focus on protein-DNA and protein-small molecule conjugates, particularly involving antibodies
• Develop and set up the coupling and immobilization protocols of protein-DNA conjugates, with a focus on antibodies
• Set up systems and workflows for purification, characterization and functional assays of custom nanostructures functionalised with various proteins, in particular antibodies
• Stay up-to-date with state-of-the-art assay technology and share expertise with various project teams
• Collaborate with a multidisciplinary team of scientists and engineers to optimize biochip performance
• Manage R&D projects with a high level of autonomy and initiative, within the constraints of a start-up environment
  
  
  

Requirements

• Ph.D. (or M.Sc. with extensive industry experience) in Chemistry, Biochemistry, (Molecular) Biology, or a related field
• Extensive expertise in bioconjugation of proteins, in particular antibodies, to DNA or small molecules in the context of assay development
• Proficiency in purification, characterization and functional assays of proteins and protein conjugates using techniques such as affinity chromatography, IE-HPLC, SEC, Western Blots and various activity assays
• Creative, proactive, and results-oriented mindset
• Excellent interpersonal and communication skills
• Fluent in English
  
  

Optional:

• Industry experience in e.g. ELISA assay development, ideally in the context of medical diagnostics
• Proficiency in bioconjugation to surfaces and/or nanoparticles
• Experience in designing, production or characterization DNA nanostructures
  
  
  

Benefits

• Shape the future of diagnostics - be at the forefront of the development of our products
• State-of-the-art technology package
• Accelerated career trajectory
• Competitive compensation and benefits structure
• An international, collaborative, and supportive work culture
• Flexible working models