Principal Investigator (Lübeck)

EPM Scientific; Berlin; On-site; EUR 122,000 - 149,000; Full time

Benefits offered by this job

Competitive salary up to 135,000 EUR

Vaccine programme with public health |

Structured clinical research support

International sponsors exposure

Long-term leadership career path

Collaborative team environment

Job summary

EPM Scientific is seeking an experienced Principal Investigator to lead vaccine-focused clinical trials across Phase I–IV in Germany. You will provide medical leadership, ensure safety and compliance, and oversee patient screening, enrolment, and site operations.

The role requires MD qualification with German licensure eligibility, strong ICH-GCP knowledge, and excellent communication. Fluency in English is essential; German language skills are desirable.

Qualifications

• MD qualification and full medical registration/licensure (Germany or eligibility)
• Proven experience as Principal Investigator, Sub-Investigator, or Research Physician
• Strong understanding of ICH-GCP guidelines and clinical trial regulations
• Excellent communication and stakeholder-management skills
• Fluent English; German language skills desirable

Responsibilities

• Act as Principal Investigator across Phase I–IV clinical trials with vaccine focus
• Provide medical leadership and oversight throughout the trial lifecycle
• Ensure participant safety, welfare and protocol compliance
• Lead screening, enrolment, eligibility assessments and visits
• Review adverse events and safety data
• Ensure studies meet ICH-GCP, local regulations and sponsor requirements
• Maintain documentation quality and protocol adherence
• Collaborate with CRCs, Study Nurses, Sub-Investigators, and Clinical Operations
• Participate in sponsor meetings, site visits, audits, and inspections
• Support patient recruitment and retention strategies
• Contribute to site growth and future research opportunities
• Mentor junior investigators and staff

Skills

MD qualification

PI experience

ICH-GCP knowledge

English fluency

Stakeholder management

German language skills

Education

Medical Doctor (MD)

Job description

Key Responsibilities

• Act as Principal Investigator across Phase I-IV clinical trials, with a particular focus on vaccine studies.
• Provide medical leadership and oversight throughout the full clinical trial lifecycle.
• Ensure participant safety, welfare, and protocol compliance at all times.
• Conduct and supervise screening, enrolment, eligibility assessments, and study visits.
• Review adverse events, serious adverse events, and safety data.
• Ensure studies are conducted in accordance with ICH-GCP, local regulations, and sponsor requirements.
• Maintain oversight of source documentation, data quality, and protocol adherence.
• Collaborate closely with Clinical Research Coordinators, Study Nurses, Sub-Investigators, and Clinical Operations teams.
• Participate in sponsor meetings, site visits, audits, and regulatory inspections.
• Support patient recruitment and retention strategies.
• Contribute to site growth initiatives and evaluation of future research opportunities.
• Mentor junior investigators and clinical research staff where appropriate.

Requirements

Essential

• Medical Doctor (MD) qualification.
• Full medical registration/licensure in Germany or eligibility to practice.
• Previous experience in clinical research as a Principal Investigator, Sub-Investigator, or Research Physician.
• Strong understanding of ICH-GCP guidelines and clinical trial regulations.
• Ability to make sound medical decisions in a research environment.
• Excellent communication and stakeholder-management skills.
• Fluent English language skills.

Desirable

• Experience within vaccine, infectious disease, immunology, public health, or preventative medicine studies.
• Prior responsibility for participant safety review and adverse event assessment.
• Experience interacting with sponsors, CROs, ethics committees, and regulatory authorities.
• GCP certification.
• German language skills.

What Is Offered

• Salary up to €135,000 per annum.
• Opportunity to work on a high-profile vaccine programme with significant public health impact.
• Established clinical research infrastructure and dedicated site support.
• Exposure to cutting-edge vaccine development and international sponsors.
• Strong long-term career progression opportunities within clinical research leadership.
• Collaborative and scientifically driven working environment.