Postdoctoral scientist (f/m/d)

Universitätsmedizin Göttingen I UMG; Göttingen; Vor Ort; EUR 48.000 - 60.000; Vollzeit

Zusammenfassung

Universitätsmedizin Göttingen I UMG invites applications for a postdoctoral scientist to study molecular mechanisms of peripheral neuropathies in Drosophila, using correlative cryo-EM workflows. The role includes generating lines, performing in situ imaging, and data analysis within an interdisciplinary lab.

Applicants should hold a Ph.D. in neurobiology or related fields with strong genetics and cell biology experience and an interest in advanced structural techniques and computational analysis.

Qualifikationen

• Ph.D. in neurobiology or related field.
• Extensive research experience in Drosophila cell biology and genetics.
• Experience with structural techniques is desirable but not mandatory.

Aufgaben

• Generate and characterize novel Drosophila lines.
• Carry out correlative cryo-light microscopy, Cryo-FIB milling and cryo-electron tomography to study neuronal architecture in intact Drosophila tissues.
• Quantitative analysis of cryo-ET data.

Kenntnisse

Drosophila biology

Neurobiology

Genetics

Ausbildung

Ph.D. in neurobiology or related field

Tools

Correlative cryo-light microscopy

Cryo-FIB milling

Cryo-electron tomography

Jobbeschreibung

The goal of the Fernandez-Busnadiego lab is to unravel the structural basis of fundamental cellular mechanisms, as well as their alterations in human disease. To that end, we employ multidisciplinary approaches, pivoting on state-of-the art cryo- electron tomography (see e.g. Bäuerlein et al., Cell 2017; Guo et al., Cell 2018; Collado et al., Dev Cell 2019; Trinkaus et al., Nat Comm 2021; Jentoft et al. Cell 2023; Wagner et al., Nature 2024; Ehses et al., Sci Adv 2026).

We are looking for a postdoctoral scientist with experience in Drosophila biology to investigate in situ the molecular mechanisms underlying peripheral neuropathies.

• generate and characterize novel Drosophila lines
• carry out correlative cryo-light microscopy, cryo-focused ion beam milling and cryo-electron tomography to investigate the molecular architecture of neurons directly within intact Drosophila tissues (see Bäuerlein et al., bioRxiv 2023)
• quantitative analyze cryo-ET data

• Ph.D. in neurobiology or related fields
• extensive research experience in Drosophila cell biology and genetics
• experience with structural techniques is also desired but not mandatory

• a stimulating intellectual environment with innovative research projects
• excellent scientific and technical infrastructure, including last-generation cryo-EM equipment and computing facilities
• opportunities for professional development, including participation in international conferences
• an interdisciplinary work environment that encourages collaboration between different fields
• diverse and interesting benefits as a UMG employee (e.g. in-house daycare center, childcare during holidays, attractive infrastructure, health and sports promotion through excellent company health management)
• location in a beautiful and historic German university town with a campus that includes the University of Göttingen, the Max Planck Institutes, the German Primate Center and other research facilities on site