Postdoc (f/m/d)

GIZ-Nord; Göttingen; Vor Ort; EUR 50.000 - 70.000; Vollzeit

Zusammenfassung

The University Medical Center Göttingen invites applications for a Postdoc (f/m/d) in the Klinik für Kinder- und Jugendmedizin. The position is full-time and initially limited to 31.05.2027, with remuneration according to TV-L.

The role combines basic and translational research on lysosomal and related neurodegenerative diseases, using patient-derived cells and iPSC models to explore disease mechanisms and therapeutic targets.

Qualifikationen

• PhD in life sciences or near completion.
• Strong hands-on background in molecular and cell biology.
• Experience with gene editing, multi-omics data integration, basic programming, or advanced imaging is desirable.

Aufgaben

• Investigate molecular mechanisms and organelle pathology underlying lysosomal diseases.
• Apply multi-omics approaches to identify dysregulated paths and therapeutic targets.
• Validate targets using genetic and pharmacological perturbations with quantitative readouts.
• Maintain patient-derived fibroblasts and iPSC models; run disease-relevant phenotypic assays.
• Develop high-throughput compatible assays for drug repurposing screenings.

Kenntnisse

Molecular biology

Cell biology

Gene editing

Multi-omics

Programming basics

Imaging

Team collaboration

Ausbildung

PhD in life sciences

Tools

CRISPR/Cas9

iPSC models

Jobbeschreibung

The Klinik für Kinder- und Jugendmedizin of the University Medical Center Göttingen is looking for a new position for the earliest start date

Postdoc (f/m/d)

full time , initially limited to 31.05.2027
Remuneration according to TV-L

We are seeking a motivated researcher to investigate the molecular pathophysiology of lysosomal and related neurodegenerative diseases and to contribute to the development of novel therapeutic approaches. Lysosomal diseases are rare, neurometabolic disorders that often manifest in childhood or adolescence. Despite their genetic heterogeneity, many share converging molecular mechanisms that overlap with classical adult-onset neurodegenerative diseases. These disorders affect both the nervous system and peripheral organs and are clinically characterized by progressive symptoms and cognitive decline. As casual therapies remain unavailable for most lysosomal diseases, this field offers a unique opportunity to drive discoveries with direct translational impact. Our research group focuses on the molecular characterization of both genetically defined and poorly understood lysosomal diseases, aiming to understand cellular pathology and develop therapeutic strategies. We work with patient-derived cells and human cell models, applying high-throughput techniques such as drug screening to accelerate discovery.

• Investigate the molecular mechanisms and organelle pathology underlying lysosomal diseases (endo-lysosomal trafficking, autophagy, secondary mitochondria disruption)
• Apply and integrate multi-OMICS (transcriptomics, proteomics, metabolomics) approaches to identify dysregulated intracellular pathways and identify therapeutic targets
• Validate targets using genetic and pharmacological perturbations (CRISPR/ Cas9, small molecules) with quantitative functional readouts (enzyme activity, lysosomal flux, imaging)
• Maintain and characterize patient-derived fibroblasts and iPSC models; implement disease-relevant phenotypic assays
• Develop and automate high-throughput compatible assays for drug repurposing screenings; analyze hits and lead follow-up studies
• Collaborate across our Göttingen network; document, present, and publish results; and contribute to reproducible workflows and data sharing initiatives
• PhD (completed or near completion) in life sciences (e.g., biology, molecular medicine, biochemistry) or a related discipline
• Strong hands-on background in molecular and cell biology with an interest in translational medicine
• Experience in gene editing, multi-omics data integration, basic program ming, or advanced imaging is desirable
• Experience with high-throughput/automation and stem cell (IPSC) models is an advantage, but not mandatory, as these skills can also be developed during the project
• High self-motivation, an independent and creative working style, and excellent teamwork and communication skills

We offer

• A collaborative neuroscience and translational research environment at the University Medical Center Göttingen (UMG), DZKJ, and Fraunhofer ITMP, with close ties to leading institutions such as the Max Planck Institute for Multidisciplinary Sciences and the DZNE
• Extensive opportunities for interdisciplinary exchange, joint projects, and direct links between basic and clinical research through local, national, and international collaborations Secure, multi-source funding (UMG, EU programs, patient organizations, DZKJ) supporting ambitious, long-term projects
• Attractive UMG employee benefits, including on-site daycare and vacation childcare, robust health and sports programs, modern infrastructure, and professional development opportunities
• A beautiful, historic university town with an exceptional concentration of research institutes (University of Göttingen, Max Planck Institutes, German Primate Center, Fraunhofer Institute, German Centers for Health Research (DZG)) and a high quality of life

The University Medical Center Göttingen (UMG) unites the Medical Faculty of the Georg-August University and the University Hospital in an integration model. With around 9,700 employees, the UMG and its subsidiaries are one of the largest employers in the region. Our clinics and institutes stand for high-quality patient care, excellent research, modern teaching and transfer of innovative technology.

Göttingen as a city of science is located in the center of Germany and the University Medical Center Göttingen is integrated into an attractive network of university and non-university scientific institutions.

Our goal as University Medical Center Göttingen is professional equality for all genders. We strive to equalize the gender ratio in areas where there is underrepresentation. The University Medical Center Göttingen is particularly committed to the professional participation of severely disabled people and therefore welcomes applications from severely disabled people. In the case of equal suitability, applications from severely disabled persons will be given preferential consideration in accordance with the relevant regulations. We kindly ask you to indicate a disability/equal status in your letter of application in order to safeguard your interests.