Doctoral Position: Gene Expression Regulation (f/m/x)

Universität zu Köln; Köln; Vor Ort; EUR 50.000 - 70.000; Teilzeit

Benefits dieser Stelle

International team

Flexible working time models

Advanced training opportunities

Zusammenfassung

The University of Cologne invites applications for a highly motivated doctoral candidate to join the Uhlirova Lab in genetics, molecular biology and systems-level analysis. You will lead an independent project, work with model organisms and cell culture, and contribute to collaborative research at the interface of biology and bioinformatics.

The position is available immediately on a part-time basis (25.89 hours/week) for three years.

Qualifikationen

• Master’s degree in Biology or related Life Sciences.
• Strong background in genetics, molecular and cell biology is essential.
• Motivation, curiosity and creativity with problem solving.
• Proven ability to carry out an independent scientific project and collaboration.

Aufgaben

• Study crosstalk between transcription and pre-mRNA splicing under various conditions.
• Investigate spliceosome assembly and functional plasticity.
• Uncover factors that affect transcript and tissue sensitivity to aberrant splicing.
• Explore how spliceosome malfunction contributes to tissue homeostasis and aging.

Kenntnisse

Genetics

Molecular biology

Cell biology

Analytical thinking

Ausbildung

Master's degree in Biology or Life Sciences

Tools

Drosophila

Mouse models

Cell culture

Jobbeschreibung

We are one of the largest and oldest universities in Europe and one of the most important employers in our region.Our broad range of subjects, the dynamic development of our main research areas and our central location in Cologne make us attractive for students and researchers from around the world. We offer a wide range of career opportunities in science, technology, and administration.

The Uhlirova lab (www.uni-koeln.de/inter-fak/cecad/control gene expression and influence tissue homeostasis and longevity. To tackle these questions, we combine the power of functional genetics in Drosophila and mousemodels with cutting-edge molecular and cell biology, multi-omics approaches, advanced microscopy, and bioinformatics. We are looking for a highly motivated and curious doctoral candidate (f/m/x) to join our dynamic team. You willhave the opportunity to lead your own project, contributeto collaborative research, and develop skills at the interfaceof genetics, molecular and cell biology, and systems-levelanalysis.

YOUR TASKS

• To study the crosstalk between transcription and pre-mRNA splicing under physiological, stress, anddisease conditions
• To investigate mechanisms underlying spliceosomeassembly and functional plasticity
• To uncover what renders different transcripts, cells,and tissues sensitive to aberrant splicing
• To investigate how spliceosome malfunctioncontributes to loss of tissue homeostasis, prematureaging and diseases

YOUR PROFILE

• Completed Master’s degree or equivalent in Biology / Biochemistry/ Biophysics or related areas of LifeSciences
• Strong background in genetics, molecular and cellbiology is essential
• Motivation, curiosity and creativity, and a strong abilityto solve problems through critical analytical thinking
• Proven ability to carry out an independent scientificproject and unwavering commitment to high-qualityresearch
• Hands-on experience in working with model organisms,preferably Drosophila and/or mouse and cell culturesystems
• Excellent communication skills, fluency in spoken and
• Strong commitment to collaboration and teamwork

DESIRED ASSETS

• Hands-on experience in multi-omics research projects and data analysis
• Experience with protein purification and biomolecular
• Interest in computational modeling of biomolecular interactions
• Experience in quantitative image analysis and attention
• Strong organizational and thorough documentation skills

WE OFFER

• Interactive and international team with access to state-of-the-art research facilities
• A diverse working environment with equal opportunities
• Support in balancing work and family life
• Extensive advanced training opportunities
• Occupational health management offers
• Flexible working time models

The University of Cologne promotes equal opportunities anddiversity. Women will be considered preferentially in accordance with the Equal Opportunities Act of North Rhine-Westphalia (Landesgleichstellungsgesetz – LGG NRW). We also expressly welcome applications from all suitable candidatesregardless of their gender, nationality, ethnic and socialorigin, religion, disability, age, sexual orientation and identity.

The position is available from immediately on a part-timebasis (25,89 hours per week).The position is to be filledfor three years. If the applicant meets the relevant wagerequirements and personal qualifications, the salary isbased on remuneration group 13 TV-L of the pay scale forthe German public sector.

The reference number is Wiss2608-13. The applicationdeadline is 27 September 2026.

For further inquiries, please contact Dr Esther Wollert([e-mail]) and take a look at our FAQs.

Faculty of Mathematics and Natural Sciences

Uhlirova Lab | Institute for Genetics | CECAD