Postdoctoral scientist (f/m/d)

Universitätsmedizin Göttingen; Göttingen; Vor Ort; EUR 45.000 - 65.000; Vollzeit

Benefits dieser Stelle

In-house daycare center

Kinderbetreuung während der Ferien

Herausragende Infrastruktur und Cryo-E

Gesundheits- und Fitnessprogramme

Zusammenfassung

Universitätsmedizin Göttingen sucht eine/n Postdoktorand/in mit Erfahrung in Drosophila-Biologie, um in situ die molekularen Mechanismen hinter peripheren Neuropathien zu untersuchen. Sie generieren neue Drosophila-Linien und führen bildgebende Verfahren auf Molekularebene in Geweben durch.

Sie arbeiten an correlative cryo-Lichtmikroskopie, cryo-FIB Milling und cryo-ET, analysieren quantitative cryo-ET-Daten und profitieren von einer exzellenten Infrastruktur sowie internationalen

Qualifikationen

• Ph.D. in Neurobiologie oder verwandten Bereichen.
• umfassende Forschungserfahrung in Drosophila-Zellbiologie und Genetik.
• Erfahrung mit strukturellen Techniken wünschenswert, aber nicht zwingend erforderlich.

Aufgaben

• Neue Drosophila-Linien generieren und charakterisieren.
• Correlative cryo-Light-Mikroskopie, cryo-FIB- Milling und cryo-ET durchführen, um die molekulare Architektur von Neuronen in intakten Drosophila-Geweben zu untersuchen.
• Quantitative Analyse von cryo-ET-Daten.

Kenntnisse

Drosophila biology

neurobiology

genetics

cryo-EM

Ausbildung

Ph.D. in neurobiology or related fields

Tools

cryo-electron tomography

cryo-FIB milling

cryo-EM data analysis

Jobbeschreibung

The goal of the Fernandez-Busnadiego lab is to unravel the structural basis of fundamental cellular mechanisms, as well as their alterations in human disease. To that end, we employ multidisciplinary approaches, pivoting on state-of-the art cryo- electron tomography (see e.g. Bäuerlein et al., Cell 2017; Guo et al., Cell 2018; Collado et al., Dev Cell 2019; Trinkaus et al., Nat Comm 2021; Jentoft et al. Cell 2023; Wagner et al., Nature 2024; Ehses et al., Sci Adv 2026).

We are looking for a postdoctoral scientist with experience in Drosophila biology to investigate in situ the molecular mechanisms underlying peripheral neuropathies.

Ihre Aufgaben

• generate and characterize novel Drosophila lines
• carry out correlative cryo-light microscopy, cryo-focused ion beam milling and cryo-electron tomography to investigate the molecular architecture of neurons directly within intact Drosophila tissues (see Bäuerlein et al., bioRxiv 2023)
• quantitative analyze cryo-ET data

Ihre Qualifikationen

• Ph.D. in neurobiology or related fields
• extensive research experience in Drosophila cell biology and genetics
• experience with structural techniques is also desired but not mandatory

Wir bieten

• a stimulating intellectual environment with innovative research projects
• excellent scientific and technical infrastructure, including last-generation cryo-EM equipment and computing facilities
• opportunities for professional development, including participation in international conferences
• an interdisciplinary work environment that encourages collaboration between different fields
• diverse and interesting benefits as a UMG employee (e.g. in-house daycare center, childcare during holidays, attractive infrastructure, health and sports promotion through excellent company health management)
• location in a beautiful and historic German university town with a campus that includes the University of Göttingen, the Max Planck Institutes, the German Primate Center and other research facilities on site