Postdoctoral position in organoid engineering and brain disease modeling (f/m/d)

ZipRecruiter; Heidelberg; Vor Ort; EUR 45.000 - 80.000; Vollzeit

Zusammenfassung

An innovative research program seeks a highly motivated scientist to develop and optimize human organoid and assembloid models. This role focuses on advancing our understanding of neurodevelopmental disorders and brain cancer through cutting-edge techniques like single-cell perturbation screening and high-content imaging. Collaborating with experts in bioengineering and computational biology, you will leverage AI-supported analytical pipelines to enhance organoid methodologies. This full-time position offers a unique opportunity to contribute to groundbreaking research in a dynamic and supportive environment. If you are passionate about organoid research and ready to make a significant impact, this is the perfect opportunity for you.

Qualifikationen

• Outstanding scientific background and excellent communication skills required.
• Proven experience in organoid technologies and mammalian cell culture.

Aufgaben

• Develop human organoid models for studying neurodevelopmental disorders.
• Establish single-cell perturbation screening approaches for disease mechanisms.

Kenntnisse

Mammalian cell culture

iPSC in vitro models

Organoid/assembloid technologies

CRISPR-based perturbation screens

Bioinformatics

Single-cell omics

Advanced imaging analysis

Ausbildung

Doctoral degree in stem cell biology

Doctoral degree in neuroscience

Doctoral degree in biomedical engineering

Doctoral degree in cancer biology

Tools

High-content imaging

MEA

Calcium imaging

Electrophysiology

Jobbeschreibung

Job Description

The position is funded by the Carl-Zeiss-Stiftung (CZS). Background: The position is embedded in the collaborative research program «Precision Organoid Engineering for Multi-Organ Interaction Studies (POEM)»: https://www.uni-heidelberg.de/en/cctp-poem. The POEM program aims to generate reproducible, micrometer-scale controllable, and cost-efficient disease models by bringing together experts in molecular systems engineering, machine learning, biomedicine, and disease modeling. Central to its objectives is the development of methods for culturing tailor-made organoids, assembloids and co-organoids for inter-organ communication towards AI-supported large-scale / high-throughput analyses.

The position will be embedded in two research groups: the group of the scientific head of the new organoid engineering lab and facility at Heidelberg University and Dr. Moritz Mall (DKFZ, Hector Institute for Translational Brain Research (HITBR)). Research will focus on building next-organ and assembloid models combined with single-cell perturbation screens to monitor cell fate decisions and functional consequences in neurodevelopmental disorders and brain cancer.

Your Role:

1. Develop and optimize human organoid and assembloid models for studying neurodevelopmental disorders and brain cancer.
2. Establish single-cell perturbation screening approaches to investigate cell fate decisions and disease mechanisms.
3. Integrate high-content imaging, single-cell transcriptomics, and functional assays (such as MEA) to assess the impact of disease mutations on neuronal biology.
4. Collaborate with bioengineers, material scientists, and computational biologists to leverage AI-supported analytical pipelines to create more reproducible organoid methodologies.

Your Profile:

1. We seek a highly motivated individual with an outstanding scientific background, excellent communication skills, and a passion for organoid research and bioengineering approaches.
2. Proven experience in mammalian cell culture, iPSC in vitro models, and organoid/assembloid technologies.
3. Hands-on experience with CRISPR-based perturbation screens.
4. Proficiency in bioinformatics, single-cell omics, or advanced imaging analysis.
5. Familiarity with functional readouts (e.g., MEA, calcium imaging, electrophysiology) is a plus.
6. Competitive applicants must have obtained an outstanding doctoral degree in disciplines such as stem cell biology, neuroscience, biomedical engineering, cancer biology, or related fields and a proven record of high-level research, for example through peer-reviewed publications and conference contributions.

This full-time position will be funded non-permanently for a limited period of initially 2 years via the CZS and remunerated according to TV-L.

Employment at Heidelberg University needs to follow the German Academic Fixed-Term Contract Act (WissZeitVG). Applications should be sent as a single PDF no later than May 15th 2025 by e-mail with subject «Application POEM 3» to Dr. Moritz Mall ([e-mail]).

Please direct any informal inquiries to Moritz Mall ([e-mail]) or Andrea Leibfried ([e-mail]). Please include a motivation letter, curriculum vitae, a list of publications, a list of current research support (if applicable), a summary of teaching experience (if applicable), a research summary, a list with 3 or more referees, including contact information. Heidelberg University stands for equal opportunities and qualified candidates are especially invited to apply. Persons with severe disabilities will be given preference if they are equally qualified.

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