Postdoc - Organic Chemistry (m/f/d)- Helmholtz-Zentrum für Infektionsforschung GmbH (HZI)

Helmholtz-Zentrum für Infektionsforschung; Braunschweig; Vor Ort; EUR 50.000 - 65.000; Vollzeit

Zusammenfassung

Das Helmholtz-Zentrum für Infektionsforschung in Braunschweig sucht einen Postdoktoranden in organischer Chemie und chemischer Biologie. Sie werden für die Entwicklung neuartiger RNA-bindender Medikamente verantwortlich sein, arbeiten in einem internationalen Team und profitieren von einer modernen Forschungsumgebung und flexiblen Arbeitsmodellen.

Leistungen

Flexible Arbeitszeiten

Home Office möglich

Teilzeitmodelle

Unterstützung für Familie und Beruf

Umfassende Weiterbildungsmöglichkeiten

Öffentliche Dienstleistungen

Mögliche Unterstützung des Jobtickets

Qualifikationen

• Hochqualifizierte wissenschaftliche Publikationen erforderlich.
• Empfohlene Kenntnisse in Deutsch und Englisch.
• Motiviert, um komplexe Synthesen zu entwerfen.

Aufgaben

• Design und Synthese neuartiger RNA-bindender Wirkstoffe.
• Zusammenarbeit mit zwei HZI-Abteilungen.
• Erhebung und Erstellung von peptidähnlichen Molekülen.

Kenntnisse

Multistep-Synthese

Organische Chemie

Analytische Werkzeuge (HPLC/MS, NMR)

Teamarbeit

Ausbildung

Ph.D. in organischer Chemie oder verwandten Bereichen

Jobbeschreibung

Fighting pathogens together!

Postdoctoral Researcher in -Organic Chemistry and Chemical Biology- (f/m/d)

Job advertisement no. : 064/2025

Starting date: As soon as possible

Duration of employment: Initial contract for 2 years

Working time: 39 hours per week

Salary: E13 TVöD Bund

Place of work: Braunschweig

Probation period: 6 months

Closing date: 10.08.2025

The departments -Chemical Biology-, led by Prof. Mark Brönstrup and -RNA Biology of Bacterial Infections- led by Prof. Jörg Vogel, at the Helmholtz Centre for Infection Research (HZI), are offering a position for a

Postdoctoral Researcher in -Organic Chemistry and Chemical Biology- (f/m/d

As a member of the Helmholtz Association, the Helmholtz Centre for Infection Research, based in Braunschweig, conducts top-level research in the field of infectious diseases. Our scientists develop novel methods and strategies to fight infectious diseases faster and more effectively. Our common goal is to develop novel approaches for the prevention, diagnosis and treatment of infectious diseases. Our research focuses on bacterial and viral pathogens, their interaction with the human immune system and new effective substances and vaccines.

The aim of the department -Chemical Biology- is to discover and characterize novel anti-infectives through screening, mode of action studies and chemical synthesis. The department -RNA Biology of Bacterial Infections- explores the RNA biology of bacterial pathogens, members of the human microbiome, as well as phages. Their main focus is now shifting to the development of programmable RNA antibiotics, also called asobiotics.

Responsibilities

The successful candidate will be responsible for the design and synthesis of novel RNA-binding drug conjugates. Such compounds should serve as next-generation precision drugs to selectively block targets in single bacterial species. The project will be conducted in close collaboration with two HZI departments, located in Braunschweig and Würzburg, and will involve the multistep synthesis of peptide-like molecules coupled to delivery units. The incumbent will get profound exposure to chemistry as well as infection biology.

Requirements

Candidates should have a completed Ph.D. degree in organic chemistry, medicinal chemistry or related areas as proven by high quality scientific publications. Candidates should be highly motivated and be able to design and conduct multistep synthesis. Profound knowledge in organic chemistry, purification and analytical tools such as HPLC/MS and NMR spectroscopy are mandatory. Interested applicants should have an overview knowledge on drug research. The ability to work in a multidisciplinary and international team is mandatory; it will involve regular business trips to Würzburg. Recommended knowledge of written and spoken German and English.

Advantageous For This Position

• Experience in peptide chemistry, conjugation chemistry and microbiological compound profiling
• First experiences in grant writing
  
  

We offer you:

• An attractive and varied job in a future-oriented research institute with an international environment at the Science Campus South in Braunschweig
• A state-of-the-art infrastructure and the latest technologies
• Flexible working hours, part-time models as well as home office
• A corporate culture of appreciation and promotion of equal opportunities
• Extensive training and continuing education opportunities to develop professional knowledge and personal skills
• A family office to support family and career as well as childcare offers
• Interesting additional public service benefits
• Possible subsidy of the job-ticket
  
  

People with severe disabilities and equivalent professional qualifications who are suitable for the position are given preference. In order to protect your rights, we ask you to provide us with a clearly recognizable reference to the existence of a degree of severe disability in your cover letter or resume.

The HZI is actively committed to equality, diversity and integration. For this reason, the HZI pursues the goal of professional equality between women and men. The position is suitable for part-time work.