Postdoc (f/m/d)

Max-Planck-Institut für Biophysikalische Chemie; München; Sur place; EUR 52 000 - 65 000; Plein temps

Avantages offerts par ce poste

On-site cafeteria

Childcare support

Health management & fitness

Sustainability campus

Résumé du poste

Max Planck Institute for Multidisciplinary Sciences in Göttingen seeks a Postdoc (f/m/d) to analyze ubiquitin ligase complexes using cryo-EM and complementary methods. The role emphasizes structural insights, advanced biophysical analyses, and collaboration across disciplines.

The successful candidate will hold a PhD in a related life science field, possess a strong cryo-EM track record, and communicate effectively within an international team.

Qualifications

• PhD or equivalent in life sciences required.
• Strong track record in single-particle cryo-EM (or cryo-ET) and protein biochemistry.
• Curiosity-driven, creative, and capable of independent work in an international team.

Responsabilités

• Perform cryo-EM analyses to reveal structural mechanisms of ubiquitin ligases.
• Integrate complementary techniques including X-ray crystallography and biophysical assays.
• Publish results and contribute to collaborative, multidisciplinary projects.

Connaissances

Cryo-EM experience

Protein biochemistry

Independence and initiative

Communication in English

Formation

PhD or equivalent in life sciences

Outils

RELION

cryoSPARC

X-ray crystallography

Description du poste

Postdoc (f/m/d)
– Cryo-EM Analyses of Ubiquitin Ligase Complexes –

At the Max Planck Institute for Multidisciplinary Sciences , we bridge the gap between basic research and translational, preclinical approaches. Here, researchers from the fields of biology, chemistry, physics, and medicine collaborate across disciplines, supported by high-performance service facilities and a modern research infrastructure. As the largest institute of the Max Planck Society with around 1,000 employees from over 66 nations, we offer an inspiring, international working environment with exceptional scientific breadth.

Postdoc (f/m/d)
– Cryo-EM Analyses of Ubiquitin Ligase Complexes –

Our laboratory aims to understand how the posttranslational modifier ubiquitin coordinates eukaryotic physiology.A major key lies in the action of ubiquitin ligases that recruit specific substrates for ubiquitination and determine which ubiquitin signals they are decorated with. The immense potential of ubiquitin ligases for therapeutic applications has been illustrated by the clinical efficacy of immunomodulatory drugs in the treatment of hematological malignancies and recent advances with PROTACs and molecular glues. However, efficient targeting of ubiquitin ligases in the clinic is still limited by our insufficient understanding of their structural mechanisms, regulation, and integration into cellular pathways.

We offer a Postdoc position focusing on revealing structural mechanisms of specificity, regulation, and substrate recognition by ubiquitin ligases. Available projects center on cryo-EM as a principle structural tool, but may also integrate other structural techniques, including X-ray crystallography, as well as biophysical and biochemical analyses of enzymatic activities and protein interactions. For a representative example of our integrated research approach, please see

Nat Struct Mol Bio l . 2024 Feb;31(2):364-377. doi: 10.1038/s41594-023-01203-4

Candidatesshould hold/soon expect a PhD or equivalent degree in a relevant area of the life sciences. A strong published track record in single-particle cryo-EM (or cryo-ET) and in protein biochemistry is essential. The successful candidate should be curiosity-driven, creative, and passionate about science. A high degree of self-motivation and independence is important, as well as the ability to communicate well within an international, multidisciplinary team.

We offer

• A stimulating and collaborative international research environment
• Professional development opportunities, skills training, and the Max Planck Society’s online training academy
• Support for balancing work and family life, including on-campus childcare
• Corporate health management, fitness and sports programs
• On-site cafeteria offering warm meals and a salad bar
• Sustainability initiatives and a nature-oriented campus environment, including a biotope

About us

Based at one of Germany’s premier research campuses, our research group has access to leading-edge infrastructure in all areas of cell and structural biology, including cryo-EM and super resolution imaging. We are an ambitious international team with English as a working language; knowledge of German is not required. The historic city of Göttingen, located in the center of Germany, offers great outdoor and cultural opportunities, a vibrant student scene, and an impressive scientific heritage.

The position is initially limited to two years, although permanent employment thereafter is not ruled out. Remuneration is based on the TVöD Bund (German federal civil service pay scale), depending on qualifications and professional experience. In addition, public sector social benefits apply.

We are committed to being a cosmopolitan institute that offers a diverse and inclusive working environment with equal opportunities. We also aim to increase the number of employees with disabilities. We welcome applications from all backgrounds.

Application

Please submit your application including a cover letter (explaining background and motivation), CV, academic transcripts, publication list, and the contact addresses of two references preferably as a single PDF file to the email address below. Review of applications will begin immediately.