Postdoc – Bioinformatics / Computational Biology

DKFZ; Heidelberg; Vor Ort; EUR 50.000 - 65.000; Vollzeit

Zusammenfassung

A leading research institution is seeking a Postdoctoral Researcher in Bioinformatics/Computational Biology to join the Division of Signaling and Functional Genomics. This role involves developing methods for analyzing genetic interactions, leading innovative projects in cancer research, and collaborating within an international team. The successful candidate will have advanced computational skills, a strong educational background, and an eagerness to contribute to high-impact scientific research.

Leistungen

30 days of vacation per year

Family-friendly working environment

Possibility of mobile work and part-time work

State-of-the-art equipment

Access to international networking opportunities

Occupational pension plan

Qualifikationen

• Academic background in bioinformatics or related fields with advanced degrees required.
• Proven experience with omics data and software development.
• Strong programming skills in Java, Python, or similar languages.

Aufgaben

• Develop bioinformatics approaches for genomic data analysis.
• Maintain software tools for high-throughput screening experiments.
• Collaborate with interdisciplinary teams on complex problems.

Kenntnisse

Omics data analysis

Analytical skills

Bioinformatics

Statistical skills

Ausbildung

PhD in bioinformatics, computer science, or related field

Master's degree in a related field

Tools

Bioconductor/R

Java

Python

Perl

MySQL

MongoDB

Git

Docker

Django

Jobbeschreibung

Social network you want to login/join with:

Postdoc – Bioinformatics / Computational Biology, Heidelberg

col-narrow-left

Client:

DKFZ

Location:

Job Category:

Other

-

EU work permit required:

Yes

col-narrow-right

Job Reference:

70c3fe0241ed

Job Views:

3

Posted:

27.06.2025

Expiry Date:

11.08.2025

col-wide

Job Description:

Postdoc – Bioinformatics / Computational Biology

Reference number: 2025-0144

• Full-time
• Signaling and Functional Genomics

“Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts – whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting.

At the earliest date possible the Division of Signaling and Functional Genomics is looking for a

We are seeking a Postdoctoral Researcher with expertise in bioinformatics and computational analysis to join the Division of Signaling and Functional Genomics led by Prof. Michael Boutros at the German Cancer Research Center (DKFZ) in Heidelberg, Germany. Our group is pioneering novel methods for high-throughput genetic and pharmacological perturbations to systematically analyze signaling pathways and gene-drug interactions. In order to decipher the genetic and gene-drug interactions, we use model systems like Drosophila, human cell cultures, and patient-derived organoids in high-throughput screens (e.g., RNAi, CRISPR/Cas9, small molecules). In this context, we also develop new computational tools for automated analysis and data visualization. These include algorithms and software applications for RNAi and CRISPR reagent identification and off-target prediction (E-RNAi, E-CRISP), and public databases of functional screening data (GenomeRNAi, GenomeCRISPR), which are also part of the ELIXIR service portfolio. Further projects in the group are based on integrative analysis of multi-omics data, such as RNASeq (bulk or single-cell) and long-read genomics data.

Your Tasks

Are you passionate about bioinformatics and eager to work in an interdisciplinary team? In our group you will work on the following tasks:

• Develop and adapt bioinformatics approaches for experimental design, data analysis, and integration of genomic data sets
• Design the concept of analysis workflows for high-throughput screens and integrative analysis
• Maintain and further develop software tools and databases for high-throughput screening experiments and add new content based on literature
• Support the group in analyzing multi-omics data, such as RNASeq and images
• Analyse and present the results
• Collaborate with internal and international collaboration partners
• Support and administer internal web- and Linux servers

Your Profile

• Academic degree (master and PhD) with a background in computer science, bioinformatics, physics, or related field
• Proven experience in omics data analysis
• Knowledge of Bioconductor/R for biological data analysis
• Experience in object-oriented software development and building of modern web-based applications
• Good analytical and (bio)statistical skills
• Knowledge of relevant programming languages such as Java, Python, and Perl
• Good knowledge of relational and document-oriented database design (e.g., MySQL, MongoDB)
• Experience with Git and Docker containers
• Knowledge of Django and workflow management systems (e.g., Snakemake or Nextflow) is beneficial
• Proficiency in applying artificial intelligence methods to biomedical data is a plus
• Experience in image processing techniques, such as segmentation, is of advantage
• Ability to quickly grasp new concepts and work independently on complex problems
• Ability to work as part of an interdisciplinary team but also independently
• Excellent communication, organizational, and interpersonal skills
• An excellent written and oral command of English is essential

The application shall include a CV, a letter of motivation, degree certificates and names, and contact information of at least two references.

We Offer

Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level

Remuneration according to TV-L incl. occupational pension plan and capital-forming payments

30 days of vacation per year

Possibility of mobile work and part-time work

Family-friendly working environment

Sustainable travel to work: subsidized Germany job ticket

Our Corporate Health Management Program offers a holistic approach to your well-being

Develop your full potential: access to the DKFZ International Postdoc Program and DKFZ Career Service with targeted offers for your personal development to further develop your talents