PhD Student “Translational Cancer Biology” – Klinik für Kinder- und Jugendmedizin

Universitätsmedizin Frankfurt; Frankfurt; Vor Ort; EUR 40.000 - 60.000; Vollzeit

Zusammenfassung

A leading medical institution in Frankfurt is seeking a highly motivated PhD student to join the pediatric oncology research group. This role involves designing CRISPR-based genetic screens and analyzing complex datasets. Candidates should have a Master's degree in life sciences, strong skills in molecular biology, and a keen interest in therapeutic research. The position offers an excellent scientific environment, mentoring, and collaboration opportunities. Apply by 08.08.2025.

Leistungen

Free public transport in Hessen

Excellent scientific environment

Participation in training programs

Mentoring opportunities

Qualifikationen

• Master's degree in life sciences or a related field.
• Strong interest in discovering novel therapeutic approaches.
• Hands-on experience with standard molecular biology techniques.
• Proficiency in bioinformatics and analysis of high-throughput datasets.
• Ability to work independently and collaboratively.
• Excellent communication skills in English.

Aufgaben

• Designing and conducting CRISPR-based genetic screens.
• Performing statistical analyses of datasets.
• Validating candidate genes and pathways in vitro and in vivo.
• Contributing to targeted therapeutic strategies.

Kenntnisse

Molecular biology techniques

Bioinformatics

Statistical analysis

Strong communication skills

English proficiency

Ausbildung

Master's degree in life sciences

Jobbeschreibung

...you're in the middle of it

We are looking for a highly motivated PhD student to join the translational pediatric oncology research group of Dr. Christian Braun at the Department of Pediatrics (Director: Prof. Jan-Henning Klusmann). Our lab investigates how dysregulated gene expression programs contribute to the development and progression of cancer, with the goal of identifying new therapeutic vulnerabilities. We combine advanced CRISPR-based screening approaches with transcriptomic and proteomic profiling, using patient-derived cancer models to explore the molecular mechanisms that drive high-risk tumors.

Your Role:

• Designing and conducting CRISPR-based genetic screens in cancer models
• Performing statistical analyses of epigenetic, transcriptomic and proteomic datasets
• Validating candidate genes and pathways in vitro and in vivo
• Contributing to the development of targeted therapeutic strategies

... your skills are what we're looking for

• Master's degree in life sciences or a related field
• Strong interest in discovering novel therapeutic approaches and understanding epigenetic mechanisms of gene regulation
• Hands-on experience with standard molecular biology techniques (e.g., cloning, PCR, flow cytometry)
• Proficiency in bioinformatics and the analysis of high-throughput datasets (e.g., RNA-seq, proteomics)
• Ability to work both independently and as part of a collaborative research team
• Excellent communication skills and proficiency in spoken and written English
• Due to legal regulations, valid proof of measles immunity / measles vaccination is required

... you'll be offered a lot

• The position (65% - E 13 ) is initially limited for 2 years with the possibility for extension
• Excellent scientific environment & dedicated mentoring
• Participation in training and qualification programs of the MSNZ and the Goethe University
• Training in novel cutting edge techniques to study epigenetic mechanisms in cancer
• Collaboration opportunities with national & international world-leading laboratories
• Free public transport in all Hessen (Free State Ticket Hessen)
• Uniklinik-Campus, Mensa, Cafés
• Insights: Instagram, YouTube, LinkedIn
• FAQ´s for new employees

It's time to join our team!

Contact: Prof. Dr. Jan-Henning Klusmann
Email: [e-mail]
Application Deadline: 08.08.2025

We welcome applications from candidates of all genders. Applicants with severe disabilities will be given preferential consideration in cases of equal personal and professional qualifications.