PhD Student (f/m/x) Frezza Lab at CECAD

TN Germany; Köln; Vor Ort; EUR 40.000 - 70.000; Vollzeit

Zusammenfassung

An established industry player is seeking a motivated researcher to explore the intricate relationship between mitochondrial function and cancer pathophysiology. This role involves utilizing advanced molecular biology and computational techniques to conduct multi-omics analyses, contributing to groundbreaking research that aims to uncover metabolic vulnerabilities for therapy and early detection markers. Join a collaborative team at a prestigious institution dedicated to shaping the future of medicine and patient care, where your insights will play a pivotal role in advancing our understanding of aging-associated disorders and cancer. Enjoy a supportive work environment with flexible hours and opportunities for professional growth.

Leistungen

Flexible Working Hours

Occupational Health Management Programs

Access to Training Programs

Qualifikationen

• Strong expertise in cellular metabolism is a plus.
• Research background in cancer biology, immunology, and/or metabolism is preferred.

Aufgaben

• Investigate the link between mitochondrial dysfunction and cancer.
• Perform multi-omics analyses and integrate datasets.

Kenntnisse

Cellular Metabolism

Statistical Methods

Communication Skills

Problem-Solving

Ausbildung

MSc in Biology

MSc in Biochemistry

MSc in Molecular Biology

Tools

Molecular Biology Techniques

Computational Techniques

Jobbeschreibung

Job Description:

• Use cell lines and mouse models to investigate the causal link between mitochondrial dysfunction and the pathophysiology of cancer.
• Use molecular biology, biochemistry, and computational techniques to investigate metabolism at the molecular level.
• Perform multi-omics analyses (metabolic, proteomic, and transcriptomic studies) and integrate these datasets to generate new hypotheses.
• Accurately record, analyze, present, and report experimental data.
• Manage your own research project under the supervision of the Principal Investigator (PI).
• Interact with and train junior members and technicians in the lab.

The successful candidate's project will be part of the "Mitochondrial regulation of cellular function" research. The focus will be on the link between mitochondrial ultrastructure and the innate immune response.

Minimum Qualifications:

• MSc in biology, biochemistry, molecular biology, or equivalent.
• Strong expertise in cellular metabolism is a plus.
• Proficiency in research procedures and statistical methods.
• Effective team player.
• Research background in cancer biology, immunology, and/or metabolism is preferred.
• Excellent communication skills in written and spoken English.
• Demonstrated curiosity-driven science and problem-solving abilities.

Additional Information:

Supportive and cooperative working environment with access to internal and external training programs. Flexible working hours to accommodate family life. Occupational health management programs.

About Us:

Working at the University Hospital Cologne and the Medical Faculty means contributing to shaping the future of medicine, patient care, and research. The Faculty of Medicine and University Hospital Cologne are involved in research, teaching, and healthcare, with a network of clinics, institutes, and numerous departments. We are committed to inclusive, equal opportunity employment, offering attractive benefits in a collegial and family-friendly environment.

Our research focuses on understanding how dysregulated metabolism contributes to aging-associated disorders, including cancer. We investigate how loss of mitochondrial enzymes like Fumarate Hydratase causes renal cancer, aiming to understand disease mechanisms, identify metabolic vulnerabilities for therapy, and discover metabolic markers for early detection and patient stratification.

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