PhD Position: High Resolution Fluorescence Imaging of Protein Plasticity (m/f/d)

International PhD Programme (IPP) Mainz; Deutschland; Vor Ort; EUR 60.000 - 80.000; Vollzeit

Zusammenfassung

A renowned research institution in Mainz is seeking motivated PhD students to work on cutting-edge research projects in the Life Sciences. This program offers exciting interdisciplinary opportunities and supports candidates from various scientific backgrounds. Successful applicants will receive access to state-of-the-art facilities and extensive training. Join a diverse community with over 200 students from 44 countries and take the next step in your scientific career.

Leistungen

Advanced training in scientific techniques

Access to state-of-the-art facilities

Fully funded positions

Qualifikationen

• Ambitious scientists looking to push the boundaries of research.
• Candidates from multiple disciplines are encouraged to apply.
• High interest and motivation are primary selection criteria.

Aufgaben

• Join a community of exceptional scientists in a lively international environment.
• Participate in interdisciplinary projects.
• Conduct research on molecular mechanisms in genome stability.

Kenntnisse

Interactive personality

Good command of English

Ausbildung

Master or equivalent

Jobbeschreibung

Organisation/Company International PhD Programme (IPP) Mainz Department Institute of Molecular Biology Research Field Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Positions PhD Positions Country Germany Application Deadline 16 Oct 2025 - 12:00 (Europe/Berlin) Type of Contract Temporary Job Status Full-time Offer Starting Date 1 Feb 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented scientists the chance to work on cutting edge research projects within the open call on “Molecular Mechanisms in Genome Stability & Gene Regulation”. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities

The research group of Edward Lemke offers the following PhD project:

In higher eukaryotes, proteins that lack an apparent folded structure are enriched in many vital processes. The Lemke group studies intrinsically disordered proteins in vital cellular processes, including transcription, nuclear transport, and healthy ageing. Since such highly dynamic systems are inaccessible to most conventional approaches, the group employs a multidisciplinary approach that combines single-molecule, microfluidics, super-resolution techniques, and chemical/synthetic biology tools.

PhD project: High Resolution Fluorescence Imaging of Protein Plasticity

We are now seeking a PhD student with a strong interest in expanding our efforts in quantitative single-molecule and super-resolution-based technologies to study protein dynamics within the context of microphase separation. While macrophase separation, leading to visible “protein/RNA” droplets, has been widely studied and suggested to be a mechanism underlying so-called membraneless organelles, potential associative mechanisms that lead to sub-resolution structures are poorly understood. However, those might play key roles in, for example, transcriptional regulation.

The project is particularly well-suited for candidates with a strong background in the physical sciences who are intensely interested in biosciences. Physicists, biophysicists, and polymer scientists, as well as physical chemists with a strong computational background, who are interested in exploring this area, are as well suited as are biologists or biochemists with a high interest in venturing into quantitative science. The project will be highly interdisciplinary, and there are multiple aspects to it that one or two different persons can fill with different interests/backgrounds.

In all cases, extensive project training will be provided. Candidates with little or no prior experience in experimental biosciences, but a strong wish to engage in these areas, are particularly encouraged to apply. High interest and motivation are the primary selection criteria, and candidates from other disciplines who wish to venture into these areas are explicitly welcome to apply.

If you are interested in this project, please selectLemke as your group preference in the IPP application platform.

Qualification profile:

Are you an ambitious scientist looking to push the boundaries of research while interacting with colleagues from multiple disciplines and cultures? Then joining the IPP is your opportunity to give your scientific career a flying start!

All you need is:

• Master or equivalent
• Interactive personality & good command of English
• 2 letters of reference

We offer

• Exciting, interdisciplinary projects in a lively international environment, with English as our working language
• Advanced training in scientific techniques and professional skills
• Access to our state-of-the-art Core Facilities and their technical expertise
• Fully funded positions with financing until the completion of your thesis
• A lively community of more than 200 PhD students from 44 different countries

For more details on the projects offered and how to apply via our online form, please visit www.imb.de/phd.

The deadline for applications is 16 October 2025. Interviews will take place at IMB in Mainz on 19 & 20 January 2026.