PhD Candidate (m/f/d) Neurohomeostasis - Department of Psychiatry and Psychotherapy

Staatliche Hochschule für Musik und Darstellende Kunst Mannheim; Bonn; Vor Ort; EUR 40.000 - 60.000; Teilzeit

Zusammenfassung

The Universitätsklinikum Bonn seeks a part-time PhD Candidate in the research group Neurohomeostasis. The position will involve studying the interplay between metabolic and psychiatric phenotypes, focusing on autophagy as a key mechanism. This role supports a cutting-edge research initiative and is an excellent opportunity for candidates interested in neuropsychiatric disorders.

Qualifikationen

• Research experience in neuropsychiatric disorders.
• Familiarity with cellular autophagy mechanisms.
• Skills in protein biochemistry and pharmacology.

Aufgaben

• Explore links between stress, proteostasis, and cellular function.
• Conduct analyses on autophagic pathways and plasma proteomics.
• Implement multidisciplinary approaches using cell models and human studies.

Kenntnisse

Protein biochemistry

Pharmacology

Advanced multi-omics techniques

Ausbildung

PhD candidate

Jobbeschreibung

The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees engage in research, teaching, patient care, and public health at the highest level. In the science ranking (LOMV) and in economic results, UKB is number 1 among university hospitals in NRW and had the third highest case mix index in 2021 among German university hospitals.

We are seeking to fill a 65% part-time PhD Candidate (m / f / d) position, available from September 1, 2025, within the research group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University Hospital Bonn.

Due to third-party funding, the position is limited to 2 years, with an additional 2 years potentially covered by a partner institution.

Our research focuses on understanding the complex links between stress, proteostasis, and cellular function, with the goal of identifying therapeutic targets for neuropsychiatric disorders. We adopt a multidisciplinary and translational approach, combining cell models, animal experiments, and human studies using protein biochemistry, pharmacology (e.g., autophagy induction, GLP-1 agonists), and advanced multi-omics techniques.

The project aims to explore the relationship between metabolic and psychiatric phenotypes by establishing cellular autophagy as a key mechanism linking brain-body interactions in stress-related disorders. Analyses will include autophagic pathways, plasma proteomics, and metabolomic polyamine profiling from human and murine samples.