Master Thesis in Epigenetic Cancer Research – Department of Medicine 2, Hematology and Oncology

Universitätsklinikum Frankfurt; Frankfurt; Vor Ort; EUR 40.000 - 55.000; Vollzeit

Zusammenfassung

Das Universitätsklinikum Frankfurt sucht nach einer engagierten Person für die Forschung im Bereich Lymphom. Die Position umfasst molekularbiologische Arbeiten und die Anwendung modernster Techniken, während Sie von erfahrenen Wissenschaftlern gecoacht werden. Ein internationales und dynamisches Arbeitsumfeld erwartet Sie, während Sie an innovativen Projekten im Bereich der Onkologie mitwirken.

Leistungen

Kollektive Arbeitsbedingungen (TV GU)

Internationale Arbeitsumgebung

Exzellente Betreuung durch einen PhD-Studenten und einen Teamleiter

Wissenschaftliche Ausbildung und Journal Club

Einblicke in die wissenschaftliche Literaturverwaltung

Qualifikationen

• Erfahrungen in molekularbiologischen und biochemischen Labortechniken von Vorteil.
• Kenntnisse in Codierungssprachen wie R und Python sind nützlich.
• Grundkenntnisse in MS Office erforderlich.

Aufgaben

• Molekularbiologische Aufgaben: Western Blotting, Zellkultur, DNA-Schadenstests.
• Genetische Modifikation von Krebszelllinien mit CRISPR-Cas9.
• Datenanalyse und wissenschaftliche Präsentation.

Kenntnisse

Enthusiasmus für biomedizinische Forschung

Hohe Motivation für experimentelle Laborarbeit

Teamfähigkeit

Verantwortungsbewusstsein

Proaktivität

Ausbildung

Eingeschrieben in einem Masterprogramm in Biologie, Biochemie oder verwandter Disziplin

Tools

R

Python

MS Office

Jobbeschreibung

...you're in the middle of it

TheDepartment of Medicine 2, Hematology/ Oncologyat theGoethe UniversityHospital Frankfurtoffers the entire spectrum of diagnostics and therapy of malignant diseases as well as a research program focusing on several cancer entities. The research laboratory of Professor Thomas Oellerich is part of the Frankfurt Cancer Institute and focuses on oncogenic signaling and therapy resistance mechanisms in lymphoma and acute myeloid leukemia. (https://lymphoma-leukemia-research-frankfurt.de/ag-oellerich/ag-oellerich-research).
The lab is furthermore funded by the German Cancer Consortium (DKTK), which was founded in 2012 as one of the six German Centers of Excellence for Health Research (DZG). DKTK aims at bringing promising results from cancer research faster into clinical development and patient care. In the DKTK more than 20 academic research institutions and university hospitals at seven partner sites cooperate with each other and the German Cancer Research Center (DKFZ) in Heidelberg as the core center (https://dktk.dkfz.de/standorte/frankfurt-mainz).

Your Role:

The project focuses on deciphering a novel cancer vulnerability in Lymphoma. The gene of interest is involved in ubiquitin and epigenetic signaling, which appear to influence B-cell development.

• Molecular biology tasks include Western Blotting, cell culture, DNA-damage and replication assays, flow cytometry and image-based assays.
• Genetic modification of cancer cell lines utilizing CRISPR-Cas9 and shRNA-mediated knockdowns
• State-of-the-Art advanced techniques such as proximity-labeling, MassSpec proteomics, RNAseq, and CHIP-seq
• Data analysis, figure generation and scientific presentations
• Bioinformatic analysis in R including exploratory data analysis, gene set enrichment analysis and figure generation utilizing ggplot and Bioconductor packages (optional)
• Code documentation with version control using GitHub (optional)

... your skills are what we're looking for

• Enrolled in a university master program in biology, biochemistry or a related discipline
• Enthusiasm and fascination for biomedical research, oncology, cell and molecular biology
• High motivation for experimental lab work
• Experiences in cell and molecular biological as well as biochemical lab techniques might be of advantage
• Experiences in coding languages such as R and Python arebeneficial
• Ability to work in a team, sense of responsibility and proactivity
• Basic knowledge in MS Office (Word, Excel)
• Due to legal regulations, valid proof of measles immunity / measles vaccination is required

... you'll be offered a lot

• Collective labour agreement TV GU
• International and cosmopolitan working environment
• Excellent tandem supervision by a PhD student (Chantal Schmidt) and a Team Leader (Dr. Niklas Dienstbier)
• Scientific education including the management of scientific literature, a bi-weekly journal club, good scientific presentation and publication practice
• Uniklinik-Campus, Mensa, Cafés
• Insights: Instagram, YouTube, LinkedIn
• FAQ´s for new employees

It's time to join our team!

Contact: Dr. Niklas Dienstbier (Team Lead - Mechanistic Lymphoma Research)
Phone or Email: 069-6301-84001 or [e-mail]
Application Deadline: 10.07.2025

We welcome applications from candidates of all genders. Women are currently underrepresented in these positions at Universitätsmedizin Frankfurt. Therefore, applications from women are especially encouraged. Applicants with severe disabilities will be given preferential consideration in cases of equal personal and professional qualifications.