Master Thesis Biology - microbiome research (m/f/d)- Helmholtz-Zentrum für Infektionsforschung GmbH

Helmholtz-Zentrum für Infektionsforschung; Braunschweig; Vor Ort; EUR 40.000 - 60.000; Vollzeit

Zusammenfassung

The Helmholtz Centre for Infection Research offers a Master’s thesis opportunity focusing on bacteriophage dynamics in the human gut ecosystem. This research position provides a unique chance to study the interactions of phages and bacteria, contributing to innovative approaches in infection management, with a competitive stipend and access to cutting-edge facilities.

Leistungen

Expense allowance of €450/month

Access to state-of-the-art infrastructure

Professional supervision during thesis

International working environment

Opportunities for professional growth

Qualifikationen

• Currently enrolled in an advanced master's program.
• Strong background in microbiology and research methodologies.
• Motivated to investigate phage-bacteria dynamics.

Aufgaben

• Investigate interactions of bacteriophages and bacteria in the gut.
• Conduct in vitro and in vivo research experiments.
• Quantify phages and assess host range through specialized assays.

Kenntnisse

Research Methodologies

Experimental Design

Data Analysis

Microbiology

Phage Therapy Understanding

Laboratory Skills

Ausbildung

Advanced Master's Program

Tools

Experimental Assays

Culturing Techniques

Biostatistical Software

Jobbeschreibung

As a member of the Helmholtz Association, the Helmholtz Centre for Infection Research, based in Braunschweig, conducts top-level research in the field of infectious diseases. Our scientists develop novel methods and strategies to fight infectious diseases faster and more effectively. Our common goal is to develop novel approaches for the prevention, diagnosis and treatment of infectious diseases. Our research focuses on bacterial and viral pathogens, their interaction with the human immune system and new effective substances and vaccines.

The Department Microbial Immune Regulation Of Prof. Dr. Till Strowig At The Helmholtz Centre For Infection Research (HZI) In Braunschweig, Germany Is Offering a Master Thesis In The Area Of Human Microbiome Research

“Characterization of Phage-Bacteria Dynamics in the Human Gut Ecosystem”

The human gut microbiome is a complex and dynamic ecosystem comprising trillions of microorganisms, including bacteria, viruses and fungi. It plays a vital role in maintaining health by contributing to digestion, regulating the immune system, and protecting against pathogens. Disruptions to this microbial balance, known as dysbiosis, are associated with various diseases, including infections, inflammatory conditions and metabolic disorders.

One group of opportunistic pathogens that can thrive during gut dysbiosis are various Klebsiella species. These bacteria can colonize the gut without causing symptoms, but they can also cause severe infections, particularly in individuals with weakened immune systems or following antibiotic treatment. Some Klebsiella strains produce cytotoxins or carry antibiotic resistance genes, making them a growing concern in hospital and community settings alike. Bacteriophage therapy, which employs viruses that specifically infect bacteria, is a promising alternative to antibiotics for treating Klebsiella infections. Phages can target pathogenic strains with high specificity while sparing the beneficial microbiota. In the context of the gut, phage therapy may help to restore microbial balance by selectively eliminating harmful bacteria. This offers a precise way of managing infections and reducing reliance on broad-spectrum antibiotics.

Activities and responsibilitiesThe objective of this study is to investigate the interactions and dynamics between bacteriophages and bacteria in the human gut ecosystem. To this end, an integrated in vitro and in vivo approach will be employed to enhance our understanding of their ecological roles and potential health implications.

Methods

• Phage quantification via spotting and plating assays
• Methods for determining the host range and specificity of phages
• Ex vivo assays with different microbiota samples, including from mice
• Culturing of intestinal bacteria
• Various in vitro competition assays between phages and bacteria
• Assistance with in vivo experiments (mice and Galleria mellonella)
  
  

Qualification profile Advanced masters programmBenefits

• An expense allowance of EUR 450 per month for a maximum of 6 months
• An exciting and varied role in a future-oriented research institute with an international environment on the Science Campus South in Braunschweig
• Access to state-of-the-art infrastructure and the latest technologies
• A corporate culture that promotes appreciation and equal opportunities
• Professional supervision and technical support during your master's thesis
• The opportunity to work on a current and practice-relevant topic in a scientific context and learn a lot in a friendly and international team
  
  

If equally qualified, severely disabled persons will be given preference. To protect your rights, please clearly indicate any severe disability in your cover letter or CV.

The HZI is committed to professional equality between women and men, and we therefore expressly welcome applications from qualified women.