Master's Thesis – Nanocarrier Development for Immune Cell Targeting (f/m/x)

Helmholtz Association of German Research Centres; Deutschland; Vor Ort; EUR 12.276 - 18.972; Teilzeit

Zusammenfassung

Helmholtz Munich invites applications for a Master’s Thesis – Nanocarrier Development for Immune Cell Targeting (f/m/x) 102909. The role is part time (20 hrs/week) in Neuherberg near Munich, with partial home office options.

The project focuses on creating LNP libraries for targeted delivery to immune cells, under supervision in the Institute for Intelligent Biotechnologies. Enrolled Master’s students in relevant fields are encouraged to apply.

Qualifikationen

• Enrolled Master's student in Bioengineering, Biochemistry, Biomedical Sciences, or related discipline.
• Solid laboratory experience is required.
• Interest in nanotechnology and drug delivery.
• Structured, independent working style with ability to work collaboratively in an interdisciplinary team.

Aufgaben

• Design and evaluation of targeting ligands (e.g., peptides).
• LNP formulation and ligand conjugation.
• Physicochemical characterization of nanocarriers.
• Library screening using barcoding approaches.
• Performance analysis in tissue‑cleared mice using light‑sheet microscopy.
• Quantitative assessment of immune organ and cell‑type targeting.

Kenntnisse

Laboratory experience

Nanotechnology interest

Team collaboration

Independent working style

Ausbildung

Master's student in Bioengineering

Tools

Peptide design tools

In silico tools

PCR / sequencing basics

Jobbeschreibung

Area of research:

Diploma & Master Thesis

Job description:

Master's Thesis – Nanocarrier Development for Immune Cell Targeting (f/m/x) 102909

Part time | 20 hrs./week

Neuherberg near Munich

Partial Home Office possible

At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we accelerate the transfer of new ideas from the lab to real‑life applications, improving lives.

At the Institute for Intelligent Biotechnologies (iBIO), our major goal is to accelerate biomedical research by developing and combining enabling technologies. Our major research fields are AI‑based organ mapping, Tissue engineering and Precision medicine in cancer treatments. Sophisticated technologies such as 3D tissue imaging, molecular profiling are combined with AI tools to decode the complexity of tissues and shed light into cancer biology. Our interdisciplinary team — comprising biologists, engineers, computer scientists, and medical researchers — develops next‑generation computational models to interpret complex biomedical data across multiple scales. Our innovations in tissue clearing, 3D microscopy, and AI‑driven pathology have been featured in leading journals (Nature Methods, Nature Neuroscience, Cell, Nature Biotechnology) and major media (The New York Times, Wall Street Journal, Süddeutsche Zeitung).

We are seeking a motivated Master's student (f/m/x) with a background in biochemistry, bioengineering, or a related field. The thesis project focuses on the development of lipid nanoparticle (LNP) libraries designed to achieve targeted delivery to immune cell populations.

Responsibilities

• Design and evaluation of targeting ligands (e.g., peptides)
• LNP formulation and ligand conjugation
• Physicochemical characterization of nanocarriers
• Library screening using barcoding approaches
• Performance analysis in tissue‑cleared mice using light‑sheet microscopy
• Quantitative assessment of immune organ and cell‑type targeting

Qualifications

• Enrolled Master's student in Bioengineering, Biochemistry, Biomedical Sciences, or related discipline
• Solid laboratory experience is required
• Interest in nanotechnology and drug delivery
• Structured, independent working style with ability to work collaboratively in an interdisciplinary team

Desirable qualifications:

• Experience with peptide design or in silico tools is a plus
• Experience in primer design, PCR, sequencing is a plus

This position has a fixed term, depending on the requirements of your study program.

We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference.

Helmholtz Munich
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute for Intelligent Biotechnologies
Ingolstädter Landstraße 1
85764 Neuherberg