PhD position / Junior Research Associate (all genders) in the field of Nephrology

Universitätsklinikum Hamburg-Eppendorf; Deutschland; Vor Ort; EUR 40.000 - 60.000; Teilzeit

Zusammenfassung

A leading research institution is seeking a candidate for a position focused on gene therapy for kidney diseases. The role involves producing AAV variants and developing targeted gene therapies, requiring a Master's degree in a relevant field and proficiency in molecular biology techniques. Join an international team dedicated to impactful research in a state-of-the-art environment.

Leistungen

Attractive compensation according to TVöD/VKA

Secure employment with meaningful work

Comprehensive onboarding and training programs

Sustainable travel subsidies

Family-friendly working environment

Excellent health and wellness programs

Qualifikationen

• Completed university degree (Master's or equivalent) in Biology, Biotechnology, or Life Sciences.
• Experience with AAV production is highly desirable.
• Excellent command of English required.

Aufgaben

• Production of AAV variants.
• Functional analysis of AAV specificity.
• Development of gene therapies for glomerular kidney diseases.

Kenntnisse

Molecular biology techniques

Gene therapy

Team spirit

Flexibility

Scientific research

Ausbildung

Master's degree in Biology, Biotechnology, or related field

Tools

PCR

Cell culture

Jobbeschreibung

Main tasks

Our research group investigates various kidney diseases, with a particular focus on glomerular damage and the resulting conditions that can lead to chronic kidney failure. This project explores approaches for cell-specific gene therapy in the glomerulus using adeno-associated viral vectors (AAV).

In this project, we will utilize available tools to modify the AAV capsid surface e.g. by displaying single-domain antibodies. This strategy aims to improve the specificity and efficiency of transgene delivery to glomerular cells. The AAVs generated in this project will be used for the for the targeted delivery of therapeutic genes, with the aim of treating glomerular diseases such as glomerulonephritis by modulating inflammatory processes.

This position is part of our graduate program within the Collaborative Research Center SFB1192. The research group is international and interdisciplinary. The working environment is state-of-the-art and located on the newly opened Campus Research II.

Main tasks:

• Production of AAV variants
• Functional analysis of AAV specificity
• Development of gene therapies using AAVs for glomerular kidney diseases

This position is initially limited to three years in accordance with WissZeitVG as well as due to third-party funding and is to be filled at 65% of the regular weekly working hours.

Your Profile

• Completed university degree (Master's or equivalent) in Biology, Biotechnology, Human Biology, Life Sciences, or a comparable field
• Strong interest in scientific research, particularly in gene therapy
• Commitment to conducting mouse experiments
• Proficiency in basic molecular biology techniques (e.g., cloning, PCR, cell culture);
  experience with adeno-associated virus (AAV) production and handling highly desirable
• Excellent command of English, given the international nature of the research group
• Team spirit, flexibility, and enthusiasm for scientific work

Immunity status

Please note that employment is contingent upon proof of immunization or immunity against the measles virus, in accordance with applicable legal and medical requirements. Documentation (e.g., vaccination certificate) must be provided before employment begins.

Our Offer

• Attractive compensation according to TVöD/VKA
• Secure employment with meaningful work and respectful collaboration
• Comprehensive onboarding and open knowledge exchange within the team
• Extensive training and further education programs at our UKE Academy for Education and Careers
• Opportunities to contribute to our "UKE INside" personnel policy through cross-professional and cross-hierarchical projects
• Sustainable travel: subsidies for the Deutschlandticket as a job ticket, and Dr. Bike bicycle service
• Family-friendly working environment: cooperation on childcare, free vacation childcare, advice for employees with relatives in need of care
• Excellent health, wellness, and sports programs
• A wide range of dining options in our staff restaurant, with additional choices available at the "Health Kitchen" cafés, bistros, and an on-site supermarket