Master Thesis Project (m / f / d) – Epigenetic Regulation of Pancreatic Cancer Cell Plasticity [...]

Responsibilities:

• Utilize modern sequencing-based molecular biology approaches (RNA-seq, ChIP-seq, HiChIP, Hi-C, PRO-seq, etc.) to test hypothesis and examine epigenetic and gene regulatory mechanisms controlling pancreatic tumor cell identity and therapy response.
• Bioinformatic analysis and interpretation of data followed by hypothesis testing and generation.
• Perform multiplex immunofluorescence staining to confirm gene regulatory mechanisms in primary tumor tissue using multispectral imaging with an Akoya PhenoImager.
• Perform tissue-based preparation of histological samples (FFPE tumor material) for single cell RNA-sequencing using the 10X Genomics technology.
• Perform advanced cell culture experiments to examine the effects of drug treatment in various translational model systems.
• Participation in internal or external research collaborations.
• Documentation of work procedures, data acquisition and analyses.

Qualifications:

• Strong work ethic and high level of self-motivation.
• Applicants must be enrolled in an accredited Master of Science program in a related field (biology, molecular biology, molecular medicine, or similar).
• Basic experience with cell culture, transfections, etc.
• Experience with molecular biology techniques (real-time PCR, Western blot, etc.).
• Strong interest in learning and gaining proficiency in bioinformatic analyses.
• Independent, goal-oriented and structured way of working and ability to work in a team.
• Confident written and spoken English skills.
• Dedication to making a difference in the lives of cancer patients through innovative and impactful research.

Additional Information:

• An exciting and international research environment.
• Excellent experience and expertise in modern epigenetic methods.
• Outstanding bioinformatic expertise.
• Extensive modern infrastructure for all methods related to the project.
• Working in a committed team, characterized by mutual appreciation and support.
• Proven track record of successfully supervising many students to completion.
• Long track record in gene regulation and cancer research.

Contact:

Scientific Director

E-mail: