Master Thesis Project (m / f / d) – Epigenetic Regulation of Pancreatic Cancer Cell Plasticity [...]

Robert Bosch Krankenhaus GmbH; Stuttgart; Vor Ort; EUR 35.000 - 55.000; Vollzeit

Zusammenfassung

Ein innovatives Unternehmen sucht einen engagierten Master-Studenten im Bereich Molekularbiologie, um an spannenden Forschungsprojekten zur Untersuchung von Tumorzellen zu arbeiten. In dieser Rolle nutzen Sie modernste molekularbiologische Techniken und Bioinformatik, um die Mechanismen der Genregulation zu erforschen. Sie werden Teil eines internationalen Forschungsteams, das sich der Verbesserung der Krebsbehandlung widmet. Diese Position bietet Ihnen die Möglichkeit, wertvolle Erfahrungen in einem unterstützenden und dynamischen Umfeld zu sammeln, während Sie zur Entwicklung neuer Ansätze in der Krebsforschung beitragen.

Leistungen

Internationale Forschungsumgebung

Moderne Infrastruktur

Unterstützendes Team

Erfahrung in epigenetischen Methoden

Qualifikationen

• Eingeschriebene Studenten in einem Master-Programm in verwandten Bereichen.
• Erfahrung mit Zellkultur und molekularbiologischen Techniken.

Aufgaben

• Durchführung von RNA-seq und anderen modernen molekularbiologischen Ansätzen.
• Dokumentation von Arbeitsabläufen und Datenanalysen.

Kenntnisse

Molekulare Biologie Techniken

Bioinformatik Analysen

Zellkultur

Englischkenntnisse

Ausbildung

Master of Science in Biologie

Tools

10X Genomics Technologie

Akoya PhenoImager

Jobbeschreibung

• Utilize modern sequencing-based molecular biology approaches (RNA-seq, ChIP-seq, HiChIP, Hi-C, PRO-seq, etc.) to test hypothesis and examine epigenetic and gene regulatory mechanisms controlling pancreatic tumor cell identity and therapy response.
• Bioinformatic analysis and interpretation of data followed by hypothesis testing and generation.
• Perform multiplex immunofluorescence staining to confirm gene regulatory mechanisms in primary tumor tissue using multispectral imaging with an Akoya PhenoImager.
• Perform tissue-based preparation of histological samples (FFPE tumor material) for single cell RNA-sequencing using the 10X Genomics technology.
• Perform advanced cell culture experiments to examine the effects of drug treatment in various translational model systems.
• Participation in internal or external research collaborations.
• Documentation of work procedures, data acquisition and analyses

Qualifications

• Strong work ethic and high level of self-motivation
• Applicants must be enrolled in an accredited Master of Science program in a related field (biology, molecular biology, molecular medicine, or similar)
• Basic experience with cell culture, transfections, etc.
• Experience with molecular biology techniques (real-time PCR, Western blot, etc.)
• Strong interest in learning and gaining proficiency in bioinformatic analyses
• Independent, goal-oriented and structured way of working and ability to work in a team
• Confident written and spoken English skills
• Dedication to making a difference in the lives of cancer patients through innovative and impactful research

Additional Information

We offer you :

• An exciting and international research environment
• Excellent experience and expertise in modern epigenetic methods
• Outstanding bioinformatic expertise
• Extensive modern infrastructure for all methods related to the project
• Working in a committed team, characterized by mutual appreciation and support
• Proven track record of successfully supervising many students to completion
• Long track record in gene regulation and cancer research (see )

Contact :

Scientific Director

E-mail :