Biologe (m/w/d)

Universitätsklinikum Erlangen; Erlangen; Sur place; EUR 42 000 - 54 000; Plein temps

Résumé du poste

Universitätsklinikum Erlangen invites applications for a highly motivated PhD candidate to work on the project P13 within the Collaborative Research Centre TRR 417, focusing on how GPR15L-dependent effects influence lymphocyte infiltration and the intestinal microbiota in colorectal cancer.

The candidate will be trained in multi-color flow cytometry, advanced mouse genetics, organoid culture systems, omics data analysis, and standard molecular biology methods, collaborating with groups across

Qualifications

• Completed Master’s degree in immunology, molecular biology, molecular medicine or related field.
• Strong interest in translational research and working in a collaborative environment.
• Excellent written and spoken English.
• Structured working style and team-oriented mindset.

Responsabilités

• Investigate impact of GPR15L on tumor microenvironment in colorectal cancer.
• Study T cell recruitment and effects on the intestinal microbiome.
• Work with in vivo and in vitro models and human samples.

Connaissances

Immunology

Molecular biology

Translational research

English

Formation

Master's degree in Immunology

Outils

Flow cytometry

Organoid culture

Mouse genetics

Bioinformatics basics

Description du poste

Our group at the University Hospital Erlangen is recruiting a highly motivated PhD candidate.

The project "P13 - Modulation of CRC development and progression by GPR15L-dependent effects on lymphocyte infiltration and the intestinal microbiota" is part of the Collaborative Research Centre TRR 417 "Cellular Communication in the Stroma of Colorectal Cancer: From Pathophysiology to Clinical Translation", a major German research consortium (Frankfurt - Freiburg - Erlangen). The PhD candidate will investigate the impact of the endogenous peptide GPR15L on the tumor microenvironment in colorectal cancer (in particular with regard to T cell recruitment and with regard to effects on the intestinal microbiome) using state-of-the art in vivo and in vitro models along with human samples.

To this end, the candidate will be trained in the following techniques:

• Multi-color flow cytometry
• Advanced mouse genetics
• State-of-the-art mouse models of colorectal cancer
• Analysis of omics data
• Organoid culture systems
• Standard molecular biology methods

Your Profile:

• Completed Master's degree (or equivalent) in immunology, molecular biology, molecular medicine or related disciplines
• Strong interest in translational research
• Excellent written and spoken English
• Structured working style
• Team-oriented mindset (you will work in a working group with more than 15 colleagues and collaborate with several groups associated to the TRR417 consortium)
• Knowledge of basic molecular biology techniques such as IHC, PCR, histology, cell culture or flow cytometry
• Experience in working with mice (Felasa B) and basic knowledge of bioinformatics is advantageous
• Possible starting date: 01.01.2027

Further information:

• https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-dr-s-zundler/
• https://www.trr417.de/