Postdoctoral Researcher (m/f/d) – Experimental Cancer Neuroscience

Klinikum der Technischen Universität München (TUM Klinikum); München; Presencial; EUR 52.000 - 65.000; Jornada completa

Descripción de la vacante

Das Klinikum der Technischen Universität München (TUM) sucht eine/n Postdoktorand/in für eine interdisziplinäre Forschungsgruppe an der Schnittstelle von Krebsbiologie, Neurowissenschaften und Tumor-Immunologie in München.

Sie arbeiten an der Rolle des Nervensystems bei Krebsentstehung, -Fortschritt und Immunreaktionen, entwickeln In vivo-Modelle und nutzen fortschrittliche räumliche und Einzelzelltechnologien sowie translationalen humanen Studienansätzen.

Formación

• PhD or equivalent doctoral degree in a relevant life-science discipline
• Erfahrung in experimenteller biomedizinischer Forschung sowie in vivo-Modellen
• Ausgezeichnete wissenschaftliche Kommunikationsfähigkeiten in Englisch

Responsabilidades

• Durchführung, Konzeption und Weiterentwicklung ambitionierter Projekte zu neuronalen Interaktionen im Krebs
• Beitrag zu neuronalen Signalen, Krebstherapien und Immunantworten
• Entwicklung und Betreuung von in vivo Tumormodellen, genetisch modifizierten Mausmodellen und komplexen Experimenten

Descripción del empleo

We are seeking an exceptional and highly motivated Postdoctoral Researcher to join our internationally active research group at the interface of cancer biology, neuroscience and tumor immunology.
Our group investigates how the nervous system shapes tumor initiation, progression, invasion, metastasis and cancer-associated symptoms, with a particular focus on pancreatic cancer and cancer neuroscience. We combine mechanistic cancer biology with neuroscience, immunology, advanced in vivo models, spatial and single-cell technologies, functional imaging and translational human studies.
Our ambition is clear: to define and lead emerging concepts in cancer neuroscience rather than merely follow them.
The laboratory operates in a highly competitive and well-funded environment with support from, among others, the European Research Council (ERC), Deutsche Forschungsgemeinschaft (DFG), Deutsche Krebshilfe and Else Kröner-Fresenius-Stiftung, and is embedded in a strong national and international network in cancer neuroscience.

Aufgaben

The successful candidate will take a central scientific role in our experimental program and will contribute to the conception, execution and development of ambitious projects addressing neural-tumor-immune interactions.

Depending on expertise, projects may include:

• mechanistic studies of neuron-cancer and neuro-immune interactions
• functional characterization of neural signaling pathways in cancer
• genetically engineered and orthotopic in vivo tumor models
• manipulation of neuronal, immune and tumor-cell populations
• advanced imaging and molecular phenotyping
• integration of molecular, cellular and spatial data with functional experiments
• development of new experimental concepts and therapeutic strategies in cancer neuroscience

A particularly important aspect of the position is the strategic management and further development of our animal experimentation platform.

This may include:

• preparation and coordination of animal study applications and amendments
• planning and supervision of complex in vivo experiments
• establishment and optimization of experimental mouse models
• management of genetically modified mouse colonies
• breeding strategy, genotyping and colony planning
• coordination with animal facilities, authorities and collaborating laboratories
• implementation of high standards in experimental design, documentation and animal welfare

Profil

We are looking for a scientist with a strong experimental background in at least one - preferably several - of the following fields: Cancer Biology | Tumor Immunology | Neuroscience | Neuroimmunology | Molecular Biology

You should have:

• a PhD or equivalent doctoral degree in a relevant life-science discipline
• substantial hands-on experience in experimental biomedical research as well as experience with in vivo models, ideally tumor models and/or neuroscience models
• strong expertise in molecular and cellular biology and the ability to independently design, troubleshoot and drive complex experiments
• excellent scientific communication skills in English
• a highly collaborative but intellectually independent working style

Particularly desirable is extensive experience with:

• animal experimentation and experimental planning and preparation or management of animal experimentation applications
• genetically engineered mouse models as well as mouse breeding and colony management
• tumor models and neuroscience or neuroimmunology techniques

Benefits

• This is not intended to be a purely technical postdoctoral position.
• We offer the opportunity to become a scientifically visible and intellectually independent member of a rapidly developing research program, with substantial room to shape projects and develop an individual research profile.
• Our goal is to attract scientists who want to build a field, not simply complete a project.
• You will work in an internationally competitive cancer neuroscience environment; ERC-, DFG-, Deutsche Krebshilfe- and foundation-funded research programs; highly interdisciplinary collaborations spanning cancer biology, neuroscience, immunology, surgery, pathology, spatial biology and computational biology
• We offe you projects with strong potential for high-impact publications and a translational environment with direct access to human cancer material and clinically relevant questions as well as an international network of leading scientists in the emerging field of Cancer Neuroscience
• EGYM well pass, corporate benefits and discounts (e.g. Käfer), cafeteria, sports and cultural offers
• Working in the heart of Munich at Max-Weber-Platz with very good accessibility by public transport such as the subway, S-Bahn or tram

Kontakt

Sarah Mößmer

Klinik und Poliklinik für Chirurgie

089 4140 2044

Weitere Informationen

If the candidates’ suitability for the position in question is equal, severely disabled applicants shall be given preference. Interview-related costs can, unfortunately, not be reimbursed.