Applied Digital Toxicology Expert - all genders

Sanofi-Aventis Deutschland GmbH; Frankfurt; Hybrid; EUR 80.000 - 100.000; Vollzeit

Zusammenfassung

Sanofi is seeking an Applied Digital Toxicology Expert to join their Frankfurt team. This role involves leading the development and application of quantitative systems toxicology approaches to predict safety of drug candidates. The ideal candidate will possess a PhD and experience in toxicology, as well as strong data analysis skills, to drive safety initiatives within drug R&D.

Leistungen

14-week paid family leave

Health and social benefits

Flexible working time models

Qualifikationen

• Experience in developing/ validating new methodologies in computational toxicology.
• Proficiency in data analysis and its application to toxicology.
• Networking and communication skills essential.

Aufgaben

• Develop scientific methodology and strategy of mechanistic systems biology models.
• Drive integration, visualization, and interpretation of safety data.
• Collaborate as a computational toxicology expert in project teams.

Kenntnisse

Data mining

Mathematical modeling

Python

Ausbildung

PhD in applied mathematics, biomathematics, systems biology or computational biology/toxicology

Tools

MATLAB

R

Jobbeschreibung

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Applied Digital Toxicology Expert - all genders, Frankfurt

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Client:

Location:

Frankfurt, Germany

Job Category:

Other

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EU work permit required:

Yes

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Job Reference:

17c647614d98

Job Views:

2

Posted:

27.06.2025

Expiry Date:

11.08.2025

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Job Description:

About the job

Our Team:

At Sanofi, computational modelling and simulation of drug safety helps us accelerate R&D for patients and supports patient safety throughout the entire research and development process. It's about harnessing data insights and leveraging mathematical models and digital twins responsibly to search deeper and solve sooner than ever before. Join our Digital Toxicology team as Computational Systems Toxicologist and you can help make it happen. Your job? Leading, developing and applying Quantitative Systems Toxicology approaches to predict safety of proteins, antibodies, nanobodies, and synthetic molecules. Provide actionable insights to medicinal chemists, toxicologists, and clinical teams for candidate selection, lead optimization, and risk mitigation by predicting organ toxicities and safety biomarkers. Drive compound safety and further enhance decision making in discovery and development projects by working with interdisciplinary teams. At Sanofi, Digital Toxicology supports both investigative needs and critical decision making throughout all phases of drug discovery and development. As part of the Preclinical Safety unit, Digital Toxicology is linked to investigative and regulatory toxicology, pathology and safety pharmacology expertise.

Main responsibilities:

• Develop scientific methodology & strategy of mechanistic systems biology models to facilitate safety data exploration and drug safety prediction at the interface between pharmaceutical drug research and development
• Drive the analysis, integration, visualization, and interpretation of safety data to contextualize toxicological findings and generate predictive analyses
• Apply mathematical models to evaluate preclinical toxicity mitigation plan
• Collaborate with project teams in R&D and provide scientific expertise as computational toxicology expert to aid toxicology representatives in the selection and optimization of large and small molecule therapeutics
• Participate in external consortia and symposia to keep current with industry trends and regulatory evolution in the systems toxicology field; represent Sanofi interests, maintaining high ethical and scientific standards.
• Author external presentations and manuscripts to contribute to scientific advancement of the toxicology field.

About you

• Experience: Hands-on experience with mathematical models, and their application in toxicology, e.g. mechanistic systems biology models, Quantitative Systems Toxicology, digital twins. Track record and demonstrated experience in developing and validating new scientific methodologies and strategies in the field of computational toxicology.
• Soft and technical skills: Excellent data mining, analysis, integration, interrogation, and interpretation skills are essential, and application to toxicology is critical. Proficiency in mathematical modelling environment, such as MATLAB or R, and programming languages such as Python. Natural strengths in networking and communication are also essential.
• Education: PhD in applied mathematics, biomathematics, systems biology or computational biology/toxicology with knowledge in pharmaceutical drug discovery and/or toxicology

Why choose us?

• Discover the opportunity to establish new paradigms for toxicology at Sanofi and be an industry leader in the systems and translational toxicology space.
• Be part of an active, highly innovative scientific organization, having diverse opportunities to collaborate globally and be highly recognized for successes
• Bring the miracles of science to life alongside a supportive, future-focused team.
• Benefit from a well-thought-out benefits package that rewards your contribution and commitment.
• We take care of you and your family with a wide range of health and social such as high-quality healthcare, numerous prevention programs and coverage for long-term illness. Our 14-week paid family leave for both parents is outstanding as well as a wide range of childcare benefits.
• Start your career at an attractive location based in Frankfurt/Germany and experience our modern working environment and benefit from hybrid, flexible working time models.

"Using the power of Computational Toxicology, we are not just predicting drug safety-we are pioneering a future where innovative methodologies transform data into life-saving insights"
Friedemann Schmidt, Head of Digital Toxicology

Pursue Progress. Discover Extraordinary.

Progress doesn't happen without people - people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. You can be one of those people. Chasing change, embracing new ideas and exploring all the opportunities we have to offer. Let's pursue progress. And let's discover extraordinary together.

At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity.

Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com!

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Diversity und Inklusion sind in den Grundwerten von Sanofi verankert und spiegeln sich in unserer Arbeitsweise wider. Wir respektieren die Vielfalt unserer Belegschaft in Hinsicht auf ihre Herkunft, Erfahrungen und Lebensweisen. Wir erkennen die Bereicherung, die diese Vielfalt birgt, und fördern Inklusion sowie eine Arbeitsumgebung, in der diese Unterschiede sich weiter entwickeln können, zur Stärkung des Lebens unserer Mitarbeiter, Patienten und Kunden.