Technical R&D - Analytical Project Lead

Elan Personal AG; Basel; On-site; CHF 140,000 - 200,000; Full time

Benefits offered by this job

World-leading pharma group

Central Basel location

Further training opportunities

Dynamic, motivated team

Green campus and modern facilities

Job summary

Roche Switzerland invites applications for a Technical R&D - Analytical Project Lead in Basel. The role focuses on analytical development for synthetic molecules, including method development with HPLC/UHPLC and MS, and cross-functional project leadership across discovery, regulatory, and quality teams.

You will mentor staff, manage external testing at CDMOs/CLOs, and drive robust control strategies to ensure clinical release and supply readiness. English proficiency required, German a plus.

Qualifications

• Master's or PhD in chemistry, pharmacy or related field.
• Min. 5 years of professional experience in analytical development of synthetic peptides.
• Strong foundation in liquid chromatography (HPLC/UHPLC) with UV, MS, fluorescence and CAD detection.
• Solid understanding of analytical chemistry, chromatographic techniques (HPLC, GC) and related methods.
• Excellent collaboration, supervision and project management skills with a structured approach.
• Digital analytics familiarity to support data-driven transformations.
• Excellent command of English.

Responsibilities

• Drive development of analytical control packages for synthetic molecules, including materials, IPCs and crude APIs.
• Contribute to portfolio delivery with efficient process analytics and modern techniques.
• Coach technicians and junior scientists as project lead and POC for project information.
• Supervise internal labs and testing activities at external CDMOs/CLOs.
• Collaborate cross-functionally with Research, Regulatory and Quality for execution.
• Author, review and approve regulatory documents while ensuring data integrity.
• Act as Chemistry Project Lead, overseeing external testing activities at CDMOs/CLOs.

Skills

Analytical development

Project leadership

Team supervision

Cross-functional collaboration

Digital analytics

English proficiency

Education

Master's or Ph.D. in chemistry or pharmacy

Tools

HPLC/UHPLC

Mass spectrometry (MS)

UV detection

GC

Job description

Roche Switzerland bridges the gap between pharmaceuticals and diagnostics. Important research and development functions are located here. For our long-term client, F. Hoffmann-La Roche AG in Basel, we are looking for a

Technical R&D - Analytical Project Lead

Background:

Pharma Technical Development (PTD) is a global team of over 2,000 experts focused on developing innovative medicines to address patients' needs.

Within PTD, Synthetic Molecules Technical Development (PTDC) specializes in drug substance, drug product, and analytical sciences. PTDC is instrumental in advancing the synthetic molecules pipeline, supporting research, early development, and clinical trials through technical innovation and collaboration.

This opportunity lies within analytical development for synthetic molecules, where cutting-edge techniques like high-performance liquid chromatography, gas/ion chromatography, and mass spectrometry are employed to develop efficient and robust analytical methods. The goal is to ensure the release of clinical trial products and their eventual commercial supply through a strong control strategy.

Tasks & Responsibilities:

• You serve as the Analytical SME/analytical project lead (APL), driving the development of state-of-the-art analytical control packages for synthetic molecules, including direct materials, IPCs, intermediates, and crude APIs.
• You actively contribute to portfolio delivery by ensuring efficient and effective process development analytics, including the adoption of modern techniques like modeling and simulation
• You coach technicians and junior scientists on project work and serving as a central point of contact for project-related information
• You supervise internal laboratory activities and / or testing activities at CLOs/CDMOs
• You collaborate cross-functionally with key partners in research and early development, Regulatory, and Quality to ensure seamless project execution and alignment.
• You author, review, and approve critical documents and regulatory dossiers (e.g., QIMPD, NDA) while ensuring compliance with quality standards and data integrity.

• You act as a Chemistry Project Lead (CPL), leading external testing activities at CDMOs or CLOs.

Must Haves:

• A Master's or Ph.D. in chemistry, pharmacy, or a related field.
• Min. 5 years of professional experience within the analytical development of synthetic peptides.
• You have a robust foundation in liquid chromatography (HPLC and UHPLC) with proficiency in various detection methods, including UV, Mass Spectrometry (MS), fluorescence, and charged aerosol detection.
• You possess a solid understanding of analytical chemistry, particularly chromatographic techniques (HPLC, GC), titrations, and various physicochemical methods.
• You demonstrate excellent collaboration, technical supervision, and project management skills, with a structured and rigorous approach
• Digital acumen to support digital transformation initiatives; familiarity with statistical analysis of analytical data is also advantageous
• You hold excellent command of the English language.

Nice to Have:

• Proficiency in German is considered a plus

What you will be offered:

• An opportunity to work in one of the world's most important pharmaceutical companies
• Modern campus with plenty of green spaces and meeting areas
• Central location in Basel
• Varied job profile
• Further training opportunities through temptraining
• Working in a dynamic and motivated team

Basel-Stadt Research Analytical Development Synthetic Peptides HPLC / UHPLC & Mass Spectrometry Analytical Project Management Regulatory Compliance & Quality Control