Senior Scientist, Crystallization & Solid-State Development

Roche Holding AG; Basel; Vor Ort; CHF 120.000 - 160.000; Vollzeit

Zusammenfassung

Roche is seeking a highly motivated Senior or Principal Scientist to join the crystallization and solid state development teams at Roche in Basel, Switzerland. You will design, optimize, and scale crystallization processes to achieve target purity and polymorph control, while collaborating with chemistry, formulation, and production teams.

The role emphasizes strong project leadership, cross-functional teamwork, and regulatory documentation exposure, with a focus on digitalization to improve

Qualifikationen

• Ph.D. in Chemical Engineering, Physical Chemistry, Materials Science, Pharmaceutical Science, or related field; pharma industry experience.
• Experience in end-to-end small molecule crystallization, filtration, drying, and purification.
• Strong foundation in solid-state chemistry and polymorphism.

Aufgaben

• Design, optimize, and scale crystallization, precipitation, and isolation processes.
• Define manufacturing design spaces ensuring robust control of drug substance quality attributes.
• Lead matrices collaborations with cross-functional teams and external partners.
• Drive innovation and digital transformation in process development.

Kenntnisse

Crystallization

Filtration

Drying

Process development

Solid-state chemistry

Polymorphism

Project management

Agile leadership

Interpersonal skills

Digitalization

Ausbildung

PhD in Chemical Engineering

PhD in Physical Chemistry

PhD in Materials Science

PhD in Pharmaceutical Science

MSc with 7-15+ years experience

Tools

Wet/dry milling

Spray drying

Precipitation

Process/molecular modeling

Jobbeschreibung

Roche is seeking a highly motivated Senior or Principal Scientist to join the crystallization and solid state development teams at Roche in Basel, Switzerland. You will design, optimize, and scale crystallization processes to achieve target purity and polymorph control, while collaborating with chemistry, formulation, and production teams.

The role emphasizes strong project leadership, cross-functional teamwork, and regulatory documentation exposure, with a focus on digitalization to improve