Technical Development Scientist

Roche Holding AG; Basel; Vor Ort; CHF 120.000 - 160.000; Vollzeit

Zusammenfassung

Roche is seeking a highly motivated Senior or Principal Scientist to join the crystallization and solid state development teams at Roche in Basel, Switzerland. You will design, optimize, and scale crystallization processes to achieve target purity and polymorph control, while collaborating with chemistry, formulation, and production teams.

The role emphasizes strong project leadership, cross-functional teamwork, and regulatory documentation exposure, with a focus on digitalization to improve

Qualifikationen

• Ph.D. in Chemical Engineering, Physical Chemistry, Materials Science, Pharmaceutical Science, or related field; pharma industry experience.
• Experience in end-to-end small molecule crystallization, filtration, drying, and purification.
• Strong foundation in solid-state chemistry and polymorphism.

Aufgaben

• Design, optimize, and scale crystallization, precipitation, and isolation processes.
• Define manufacturing design spaces ensuring robust control of drug substance quality attributes.
• Lead matrices collaborations with cross-functional teams and external partners.
• Drive innovation and digital transformation in process development.

Kenntnisse

Crystallization

Filtration

Drying

Process development

Solid-state chemistry

Polymorphism

Project management

Agile leadership

Interpersonal skills

Digitalization

Ausbildung

PhD in Chemical Engineering

PhD in Physical Chemistry

PhD in Materials Science

PhD in Pharmaceutical Science

MSc with 7-15+ years experience

Tools

Wet/dry milling

Spray drying

Precipitation

Process/molecular modeling

Jobbeschreibung

Chez Roche, vous pouvez être vous-même et être apprécié pour les qualités uniques que vous apportez. Notre culture encourage l'expression personnelle, le dialogue ouvert et les connexions authentiques, où vous êtes valorisé, accepté et respecté pour ce que vous êtes, vous permettant de prospérer tant personnellement que professionnellement. Voici comment nous visons à prévenir, arrêter et guérir les maladies et à garantir à chacun l'accès aux soins de santé aujourd'hui et pour les générations à venir. Rejoignez Roche, où chaque voix compte.

La position

Roche is seeking a highly motivated and passionate Senior or Principal Scientist to join the crystallization and solid state development teams at Roche in Basel, Switzerland. The successful candidate will work in the Particle Design section within the small molecule organization and develop and scale up novel crystallization and precipitation processes in close collaboration with chemistry and formulation colleagues in development and production. The ideal candidate will have a strong background in crystallization, filtration and drying, and have the ability to apply chemistry and chemical engineering principles to solve challenging problems. Additionally, the candidate should have a strong affinity for digitalization to drive innovation and efficiency in process development.

As part of the crystallization team, you will work in a highly dynamic and cross-functional environment within the PTDC-P organization. You will be responsible for developing chemical processes that achieve the necessary purity, crystal form (polymorph) and particle properties. The successful candidate is additionally expected to drive research efforts and implement new technologies that solve key CMC problems.

The position is located at the interface between synthetic and analytical chemistry and formulation and requires close collaboration with functional stakeholders. The candidate should exhibit excellent interpersonal skills for effective collaboration with interdisciplinary teams and demonstrate a solid understanding of end-to-end process development for small molecules. Frequent presentations and team interactions are expected. The candidate will also be responsible for authoring filing documents to regulatory authorities.

The Opportunity

• Design, optimize, and scale phase-appropriate crystallization, precipitation, and isolation processes under non-GMP and cGMP conditions to achieve target purity, crystal forms (polymorphs), and physical particle attributes.

• Define commercial manufacturing design spaces and operating ranges, ensuring robust control over drug substance quality attributes through a mechanistic understanding of underlying physical chemistry principles.

• Serve as a key technical interface within the Particle Design section (PTDC-P) in Basel, bridging synthetic chemistry, analytical development, production, and formulation to resolve complex solid-state pipeline challenges.

• Drive innovation and digital transformation by applying advanced process development tools, molecular or process modeling, and new solid-state methodologies to optimize particle properties.

• Author and review comprehensive technical reports, cGMP manufacturing instructions, process validation documentation, and key technical sections for regulatory filing submissions.

• Lead internal and external matrix collaborations, coordinating with cross-functional project teams, vendors, and academic partners to solve complex CMC (Chemistry, Manufacturing, and Controls) challenges.

• Expand unit operation strategies by leveraging techniques such as wet/dry milling, spray drying, or co-processing, especially for challenging small molecules, peptides, or semicrystalline materials.

• Actively contribute to and advance the internal and external scientific community by sharing technical expertise, presenting research findings, and implementing cutting-edge technologies.

Who You Are

• Ph.D. in Chemical Engineering, Physical Chemistry, Materials Science, Pharmaceutical Science, or a related field with 0-5 years of pharmaceutical industry experience (or an M.Sc. with 7-15+ years of relevant industry experience).

• Proven scientific expertise in end-to-end small molecule crystallization, filtration, drying, and purification processes, supported by a strong foundation in solid-state chemistry and polymorphism.

• Hands-on familiarity with physical powder/particulate characterization techniques and process technologies like wet/dry milling, spray drying, precipitation, or process/molecular modeling.

• Demonstrated track record in project management, matrix leadership, and agile decision-making, with the ability to prioritize and drive deliverables in a dynamic environment.

• Strong collaborative mindset with exceptional interpersonal and communication skills, enabling effective cross-functional work across chemistry, formulation, and production teams.

• Proactive problem-solver and innovative thinker who thrives on troubleshooting complex experimental challenges, embracing new ideas, and translating scientific concepts into scalable solutions.

• Excellent command of written and spoken English for technical documentation and global presentations; working knowledge of German and experience authoring regulatory filing documents are strong assets.

Qui nous sommes

Un avenir plus sain nous pousse à innover. Ensemble, plus de 100 000 employés à travers le monde sont dédiés à faire progresser la science et à garantir à chacun l'accès aux soins de santé aujourd'hui et pour les générations à venir. Nos efforts aboutissent à plus de 26 millions de personnes traitées avec nos médicaments et plus de 30 milliards de tests réalisés avec nos produits de Diagnostique. Nous nous encourageons mutuellement à explorer de nouvelles possibilités, à favoriser la créativité et à conserver nos grandes ambitions, afin de fournir des solutions de santé qui changent des vies et ont un impact mondial.

Construisons ensemble un avenir plus sain.

Roche est un employeur offrant l'équité en matière d'emploi.