Subject Matter Expert Solid State Science

Roche; Basel; Vor Ort; CHF 90.000 - 120.000; Vollzeit

Zusammenfassung

Roche in Basel, Switzerland, is seeking a Subject Matter Expert (SME) in solid-state characterization for its Pharmaceutical Research and Early Development organization. The ideal candidate will lead cross-functional efforts to define the optimal solid-state form and manage lifecycle materials from biopharmaceutical assessments to crystallization processes.

The position demands a Ph.D. and expertise in solid-state techniques like XRD and DSC, along with proven project management skills. Roche promotes a diverse and inclusive workplace.

Qualifikationen

• Ph.D. in Pharmaceutical Sciences, Chemistry, Material Science, or a related field.
• Deep understanding of solid-state analytical techniques.
• Proven ability to lead complex projects in a matrix environment.

Aufgaben

• Lead the identification of the optimal solid-state form.
• Assume full responsibility for lifecycle management of materials.
• Spearhead the evaluation and selection of global external partners.

Kenntnisse

Solid-state analytical techniques

Project management

Communication skills

Problem-solving

Ausbildung

Ph.D. in Pharmaceutical Sciences, Chemistry, or Material Science

Tools

XRD

DSC

TGA

DVS

Microscopy

Jobbeschreibung

The Position

In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. TMo, the Therapeutic Modalities organization, is accountable for translating disease biology into high‑quality drug candidates across small molecules, large molecules, oligonucleotides, and genomic medicines. By integrating deep modality expertise with cross‑disciplinary collaboration, TMo drives innovation to enable differentiated, sustainable therapeutic impact. We are CMC experts and build our strength on a broad diversity of technical expertise in chemistry, formulation design, material science, and analytical chemistry, delivering and innovating in the space of small molecules, peptides, and nucleic acid based medicines. As Subject Matter Expert (SME) you will lead the identification of the optimal solid‑state form, ensuring that early‑stage candidates possess the necessary solubility and stability to succeed in the clinic. You will serve as the central hub, coordinating complex screening and characterization activities across internal labs and global external partners. You will lead cross‑functional efforts to de‑risk drug candidates and define the “Golden Form” that carries our therapies from the lab to the patient.

The opportunity

• Scientific Leadership: Act as the single point of accountability for the solid‑state strategy of assigned projects, ensuring the selection of optimal salt, polymorph, and particle forms to support both stability and bioavailability.
• End‑to‑End Ownership: Assume full responsibility for the lifecycle management of materials, from the initial integration of biopharmaceutical assessments to the final definition of robust crystallization processes.
• Cross‑Functional Integration: Orchestrate the interface between Chemistry, Analytics, and Formulation teams to harmonize the material science narrative throughout the drug development lifecycle.
• Strategic Oversight: Spearhead the evaluation, technical vetting, and selection of global external CRO/CMO partners. You will orchestrate these collaborations, governing the seamless exchange of scientific methodologies while ensuring data generation meets our rigorous standards for quality and project milestones. You will manage the balance between internal technical services and external outsourcing partners, ensuring high‑quality data generation and proactive risk mitigation.
• Innovation Driver: Champion the adoption of digitalization and automated screening tools to enhance data analysis throughput and accelerate project cycle times.

Who you are

• Ph.D. in Pharmaceutical Sciences, Chemistry, Material Science, or a related field, with a strong focus on solid‑state characterization and crystallization.
• Deep understanding of solid‑state analytical techniques (e.g., XRD, DSC, TGA, DVS, microscopy) and their application in a pharmaceutical development context.
• Proven ability to lead complex projects in a matrix environment, with the communication skills necessary to translate technical data into strategic decisions for non‑expert stakeholders.
• Experience managing external CRO/CMO relationships and a track record of driving process improvements, particularly in implementing digital solutions.
• A proactive, solution‑oriented approach with the ability to manage diverse interfaces and adapt to an evolving, fast‑paced R&D environment.

Roche is an Equal Opportunity Employer.