Principal Scientist, siRNA Design & AI-Driven Therapeutics

F. Hoffmann-La Roche AG; Basel; Vor Ort; CHF 100.000 - 130.000; Vollzeit

Zusammenfassung

F. Hoffmann-La Roche AG in Basel is looking for a Principal Scientist to lead the design and optimization of therapeutic siRNA. This role requires deep expertise in siRNA/RNAi design, collaborating closely with project teams and AI specialists.

The ideal candidate holds a Ph.D. and has over 5 years of relevant industry experience. Responsibilities include developing novel chemical modifications and ensuring alignment across therapeutic development phases.

Qualifikationen

• 5+ years of industry experience specifically in siRNA/RNAi therapeutic design.
• Deep understanding of the RNAi mechanism and profiling of siRNA therapeutics.
• Hands-on experience with command-line utilities and scripting languages for biological sequence analysis.

Aufgaben

• Lead the drug design strategy for oligonucleotides with a focus on siRNAs.
• Develop and invent new chemical modification patterns and sequence selection strategies.
• Work in close partnership with AI experts to refine machine-learning models.

Kenntnisse

siRNA therapeutic design

computation and empirical approaches

biological sequence analysis

communication skills

Ausbildung

Ph.D. in Molecular Biology, Bioinformatics, or related field

Tools

command-line utilities

scripting languages

Jobbeschreibung

F. Hoffmann-La Roche AG in Basel is looking for a Principal Scientist to lead the design and optimization of therapeutic siRNA. This role requires deep expertise in siRNA/RNAi design, collaborating closely with project teams and AI specialists.

The ideal candidate holds a Ph.D. and has over 5 years of relevant industry experience. Responsibilities include developing novel chemical modifications and ensuring alignment across therapeutic development phases.