Oligonucleotide Chemistry Scientist, siRNA/ASO Innovation

Roche; Basel; On-site; CHF 140,000 - 190,000; Full time

Job summary

Roche in Basel seeks an experienced Scientist in Oligonucleotide Chemistry to translate advanced chemical concepts into optimized lead candidates for siRNA and ASO programs within pRED. You will champion the rational design framework and work with discovery teams to accelerate development through data-driven decisions.

You will stay at the forefront of delivery technologies and collaborate across biology, pharmacology, and toxicology to ensure therapeutic impact.

Qualifications

• Ph.D. in Oligonucleotide Chemistry, Organic Chemistry, or related discipline with 3–5 years of industry experience.
• Expertise translating chemical modifications of oligonucleotides into drug candidate designs.
• Understanding of 2'-O-methyl, 2'-fluoro, LNA and cEt modification patterns and their effects.

Responsibilities

• Design and champion the rational chemical modification framework for next-generation oligonucleotides (siRNAs and ASOs).
• Collaborate with computational experts and synthesis teams to create high-value libraries.
• Analyze experimental data with computational methods to refine chemical designs.
• Translate innovative concepts into synthetically accessible structures with precision.

Skills

Oligonucleotide Chemistry

Organic Chemistry

Chemical Modifications

Drug Design

Collaboration

Education

PhD in Oligonucleotide Chemistry

PhD in Organic Chemistry

Job description

Roche in Basel seeks an experienced Scientist in Oligonucleotide Chemistry to translate advanced chemical concepts into optimized lead candidates for siRNA and ASO programs within pRED. You will champion the rational design framework and work with discovery teams to accelerate development through data-driven decisions.

You will stay at the forefront of delivery technologies and collaborate across biology, pharmacology, and toxicology to ensure therapeutic impact.