PhD in Skin Immunology & Metabolic Reprogramming

Insel Gruppe; Bern; On-site; CHF 52,000 - 66,000; Full time

Job summary

Inselspital Bern, in the Department of Dermatology, invites applications for a four-year PhD project led by Prof. Christoph Schlapbach.

The project investigates how metabolic pathways regulate skin-resident memory TH cells and relapse in psoriasis, using human immunology, multi-omics, and advanced skin models. The position requires a MSc in natural sciences, fluency in English, strong motivation, and commitment to academic research; admission to the Graduate School for Cellular and Biomedical

Qualifications

• A degree in natural sciences (MSc) acceptable for matriculation at a Swiss University.
• Fluency in English (oral and written).
• Dedication to science and academia.
• Theoretical & practical skills in immunology, molecular, & cellular biology.
• Academic excellence, a professional work attitude, and a proactive and self-driven work ethic.
• Enthusiastic and highly motivated.

Responsibilities

• Isolation and functional characterization of human memory T-cell subsets.
• Multi-parameter flow cytometry and fluorescence-activated cell sorting.
• CRISPR/Cas9 genome editing and RNA interference.
• Metabolic phenotyping using seahorse extracellular flux analysis.
• Bulk, single-cell and spatial transcriptomics.
• Human skin explant skin culture models.
• Immunofluorescence and Immunohistochemistry.
• Bioinformatic analysis of transcriptomic datasets.

Skills

Immunology

Molecular biology

Cell biology

English (oral and written)

Proactive work ethic

Team collaboration

Education

MSc in natural sciences

Tools

CRISPR/Cas9

RNA interference

Flow cytometry

Transcriptomics

Bioinformatics

Job description

Inselspital Bern, in the Department of Dermatology, invites applications for a four-year PhD project led by Prof. Christoph Schlapbach.

The project investigates how metabolic pathways regulate skin-resident memory TH cells and relapse in psoriasis, using human immunology, multi-omics, and advanced skin models. The position requires a MSc in natural sciences, fluency in English, strong motivation, and commitment to academic research; admission to the Graduate School for Cellular and Biomedical