RNA Biology & Oligonucleotide Screening Scientist

Roche; Basel; On-site; CHF 90,000 - 120,000; Full time

Job summary

Roche in Basel is seeking an experienced Lab Associate focused on molecular biology and RNA biology to join our Nucleic-acid-based medicines team. You will set up and perform various molecular assays, including qPCR, DRUG-Seq, BRB-Seq, and RNA-Seq, to advance oligonucleotide-based therapies.

The role emphasizes cell culture, RNA handling, and lab automation within an industrial setting and requires strong organization and teamwork.

Qualifications

• B.Sc in molecular biology or related field with a minimum of 10 years experience in drug discovery or an M.Sc with a minimum of 5 years experience.
• Experience with therapeutic oligonucleotides, including screening and in vitro characterization.
• Hands-on wet-lab experience with molecular biology, RNA biology techniques (qPCR) & lab automation, ideally in an industrial setup.
• Strong organizational skills and attention to detail.
• Ability to work collaboratively in a team environment.

Responsibilities

• Develop cell-based screening assays and perform cell culture maintenance.
• Implement lab automation for high throughput screening of oligonucleotides.
• Purification and handling of RNA samples.
• Perform digital PCR, quantitative PCR (qPCR) assays to support portfolio and platform projects.
• Prepare and process tissue samples from animal studies for subsequent molecular analyses.
• Assist in setting up and executing advanced molecular biology assays, including transcriptome profiling (e.g., DRUG-Seq, BRB-Seq, RNA-Seq).

Skills

Therapeutic oligonucleotides

qPCR

RNA biology techniques

Lab automation

Team collaboration

Organizational skills

Education

B.Sc in molecular biology

M.Sc in molecular biology

Tools

qPCR

Digital PCR

RNA-Seq

DRUG-Seq

BRB-Seq

Job description

Roche in Basel is seeking an experienced Lab Associate focused on molecular biology and RNA biology to join our Nucleic-acid-based medicines team. You will set up and perform various molecular assays, including qPCR, DRUG-Seq, BRB-Seq, and RNA-Seq, to advance oligonucleotide-based therapies.

The role emphasizes cell culture, RNA handling, and lab automation within an industrial setting and requires strong organization and teamwork.