Discovery Cellular Assays , Contract 6 Months

Monte Rosa Therapeutics, Inc; Basel; Vor Ort; CHF 111.000 - 166.000; Vollzeit

Zusammenfassung

Monte Rosa Therapeutics, Inc. seeks a hands-on Contractor - Discovery Cellular Assays to advance our hit-to-lead activities. You will develop and execute cell-based assays, engineer cell lines, and optimize workflows with cross-functional teams.

Strong mammalian cell culture, gene editing, and molecular biology skills are essential. You will collaborate with scientists and CROs, implement diverse detection platforms, and contribute to scalable, reproducible assays for profiling compounds.

Qualifikationen

• Bachelor's degree or equivalent in Biochemistry, Biotechnology, Cell Biology or Molecular Biology.
• 2-3+ years of relevant cellular/molecular biology experience.
• Hands-on mammalian cell culture and cell-line engineering experience.
• CRISPR/Cas9 gene editing and engineered cell lines experience desired.
• Experience with cell-based assay development and drug-discovery context preferred.
• Protein extraction and Western blotting experience.
• Familiarity with fluorescence, luminescence, TR-FRET or AlphaScreen platforms.
• Experience with high-throughput screening or automation is a plus.

Aufgaben

• Design, develop, and execute cell-based assays for profiling and MoA studies.
• Perform molecular biology methods including cell culture and gene editing.
• Generate, isolate, and characterize engineered cell lines.
• Handle DNA/RNA isolation, analysis, and protein work.
• Interpret dose-response and assay data; communicate results to teams.
• Maintain accurate records and reagents; ensure GMP-like practices.
• Collaborate with internal and external partners; support workflow improvements.

Kenntnisse

Mammalian cell culture

Cell-line engineering

Molecular biology

Assay development

Data analysis

Ausbildung

Bachelor's degree in Biochemistry / Biotechnology / Cell Biology / Molecular Biology

Tools

Automated liquid handling

Flow cytometry

Jobbeschreibung

Overview

Monte Rosa Therapeutics is seeking a hands‑on and highly motivated Contractor - Discovery Cellular Assays to support our Discovery pipeline. The successful candidate will bring strong expertise in mammalian cell culture, cell-line engineering, cellular assay development, and molecular biology.

In this role, you will help advance our hit‑to‑lead activities by developing and implementing robust cellular assays, generating and characterizing novel cellular models, introducing new assay technologies, and continuously improving experimental workflows. You will work closely with scientists across functions and may also collaborate with external partners and CROs.

Responsibilities

• Design, develop, optimize, and execute cell-based assays to support compound profiling and mechanism-of-action studies
• Perform a broad range of molecular and cellular biology techniques, including:
  • Mammalian cell culture and cell-line maintenance
  • CRISPR/Cas9-mediated gene editing, including knock-in/knock-out approaches
  • Generation, isolation, and characterization of engineered cell lines
  • DNA/RNA isolation and analysis
  • Protein extraction, quantification, and Western blotting
  • Functional cellular readouts such as proliferation, viability, reporter assays, and cytokine measurements
• Implement and execute assays using a range of detection technologies, including fluorescence, luminescence, TR-FRET, AlphaScreen, or related platforms
• Develop and optimize assay protocols, including appropriate controls, assay conditions, and performance parameters, and troubleshoot experimental challenges independently
• Support the transition of assays from development into reproducible and scalable workflows suitable for compound profiling and screening
• Utilize automated liquid-handling systems and laboratory robotics where appropriate
• Analyze and interpret experimental data, including dose-response and other quantitative assay data, and communicate results and conclusions clearly to project teams
• Maintain accurate experimental records, protocols, and data in accordance with company procedures and good laboratory practices
• Prepare cell banks, reagents, and stock solutions and ensure the availability and quality of key experimental materials
• Collaborate effectively with internal cross-functional teams and external partners/CROs to execute experimental plans and resolve technical issues
• Contribute to continuous improvement of laboratory processes, assay platforms, and experimental workflows
• Ensure compliance with laboratory safety procedures and applicable company guidelines

Qualifications

• Bachelor's degree or equivalent in Biochemistry, Biotechnology, Cell Biology, Molecular Biology, or a related Life Sciences discipline
• 2-3+ years of relevant industry or research experience in cellular and molecular biology
• Strong hands‑on experience with mammalian cell culture and cell-line generation/engineering is essential
• Practical experience with CRISPR/Cas9 gene editing and characterization of engineered cell lines is highly desirable
• Experience with cell-based assay development and execution, ideally in a drug discovery or compound-profiling environment
• Experience with protein extraction and Western blotting
• Familiarity with assay technologies such as fluorescence, luminescence, TR-FRET, AlphaScreen, or related homogeneous assay platforms
• Experience with high-throughput screening, automation, or liquid-handling platforms is a plus