PhD: Dolichol–Cholesterol Regulation & Mevalonate Pathways

KU Leuven; Vlaams-Brabant; Presencial; EUR 45.000 - 55.000; Jornada completa

Descripción de la vacante

KU Leuven in Leuven invites applications for a fully funded PhD position investigating the regulation of dolichol synthesis and its link to cholesterol metabolism. The project, supported by the ERC Starting Grant, involves CRISPR/Cas9 gene editing, cellular models and multi-omics approaches.

The successful candidate will join Prof. Matthew Wilson's Laboratory within the GPURE subsection, collaborate across an international network, and contribute to cutting-edge research at a top European

Formación

• Master's degree with excellent results and a distinction or above.
• Passion for science and commitment to completing a four-year doctoral program.
• Creative, dynamic and analytical mindset.
• Excellent spoken and written English (C1).
• Prior training in standard molecular biology techniques and cell culture.
• Ability to work in a group and pursue independent research goals; strong communication skills.

Responsabilidades

• Identify and study interactions between dolichol intermediates and mevalonate pathway genes.
• Generate cellular models using CRISPR/Cas9 and related methods.
• Conduct luciferase-based assays for transcriptional regulation pathways.
• Perform RNA-Seq and bioinformatics analyses to map regulatory networks.
• Collaborate on LC-MS lipid/metabolomics analyses and share results in meetings.
• Supervise bachelor/master students and present data at conferences.

Conocimientos

Excellent English (C1)

Molecular biology techniques

Cell culture

Educación

Master's degree in Biomedical Sciences, Medicine, Pharmacy, Biochemistry, Bioengineering, Biology or related field

Descripción del empleo

KU Leuven in Leuven invites applications for a fully funded PhD position investigating the regulation of dolichol synthesis and its link to cholesterol metabolism. The project, supported by the ERC Starting Grant, involves CRISPR/Cas9 gene editing, cellular models and multi-omics approaches.

The successful candidate will join Prof. Matthew Wilson's Laboratory within the GPURE subsection, collaborate across an international network, and contribute to cutting-edge research at a top European