Formulation/Process Senior Scientist (LNP), Parenterals and Liquid Development (temporary role 5yrs)

Johnson Johnson; Beerse; Sur place; EUR 90 000 - 140 000; Plein temps

Résumé du poste

Johnson & Johnson in Beerse, Belgium, is seeking a Senior Scientist, Parenterals & Liquids Development to lead formulation and process development for lipid nanoparticle–based drug products intended for RNA delivery. Be part of the Drug Product Research and Development team driving innovative parenteral and liquid dose forms from discovery to late clinical stages.

You will design scalable formulations, optimize manufacturing processes such as filtration and fill-finish, and collaborate across

Qualifications

• Bachelor's degree in Pharmaceutical/Chemical Engineering or Biochemistry with relevant experience.
• Master's degree with 4 years of related experience in drug product development.
• PhD with 2 years of related experience in formulation science.

Responsabilités

• Formulate and develop parenteral and liquid dosage forms with a focus on LNP/t-LNP systems for RNA delivery.
• Lead scale-up, tech transfer, and clinical manufacturing support; contribute to regulatory submissions.
• Collaborate with Protein development, Chemistry, Process engineering, Analytical Development and external partners.

Connaissances

LNP

t-LNP

RNA delivery

Formulation development

Process development

Tech transfer

Formation

Bachelor's degree in Pharmaceutical/Chemical Engineering or Biochemistry

Master's degree with 4 years of experience

PhD with 2 years of experience

Description du poste

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com .

Job Function

Discovery & Pre-Clinical/Clinical Development

Job Sub Function

Pharmaceutical Product R&D

Job Category

Scientific/Technology

All Job Posting Locations

Beerse, Antwerp, Belgium

Job Description

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Senior Scientist, Parenterals & Liquids Development located in Beerse, Belgium.

Purpose

Within Drug Product Research and Development (DPRD) we are seeking a Formulation/Process Senior Scientist with a primary focus on Lipid Nanoparticle (LNP) and targeted Lipid Nanoparticle (t-LNP) technologies in the Parenterals & Liquids Development (PLD) department. In the PLD team, we are at the forefront of innovation. We develop groundbreaking Parenteral and Liquid drug product formulations and processes across our R&D Synthetics portfolio (small molecules, peptides, oligonucleotides) from late Discovery to Commercialization. This portfolio covers a variety of formulation types such as solutions, (nano)suspensions, liposomes, lipid-based systems, biodegradable microspheres and rods for various administration routes. This position is focused on expanding our capabilities in LNP and t-LNP systems for the delivery of RNA-based therapeutics. As a Senior Scientist within the team, you will primarily contribute to the development of innovative t-LNP drug products from early development through late clinical stages and commercialization - while also contributing your formulation and process expertise across the broader range of technologies developed within the PLD team. You will lead and implement formulation and process development activities supporting the design, characterization, scale-up, and tech transfer for clinical translation of t-LNP as well as other drug delivery platforms. You will work closely with multidisciplinary teams including RNA drug substance development, Protein development, Chemistry, Process engineering, Analytical development, Pharmaceutical and Material sciences, Clinical supply, and external partners to advance the cutting-edge delivery platform.

You will be responsible for

• Performs formulation and process development activities for innovative parenteral and liquid dosage forms across our R&D Synthetics portfolio, with strong focus formulation and process optimization of lipid nanoparticle (LNP) and targeted lipid nanoparticle (t-LNP) systems intended for the delivery of RNA and other advanced therapeutics.
• Develop and optimize LNP manufacturing processes, including nanoparticle formation, TFF, conjugation, sterile filtration, and fill-finish considerations. Performs hands-on laboratory work and collects results in electronic lab notebook and reports.
• Provide technical leadership for scale-up, technology transfer, and clinical manufacturing activities. Contribute to regulatory submissions, patent applications, tech transfer reports and documentation.
• Collaborates with various internal partners in Drug Development such as Protein development, Chemistry, Process engineering , Pharmaceutical & Material Sciences, Analytical Development and Pharmaceutical Supply & Engineering Sciences and collaborates with external industrial partners, academic partners and CDMOs.
• Develops expertise in assigned technical areas, searches the academic and patent literature to identify current practices, gaps and opportunities relating to the scientific field, and translates new insights into patient-centric solutions in support of drug development.

Qualifications / Requirements

Education

Minimum of a Bachelor's degree in Pharmaceutical/Chemical Engineering or Biochemistry with 6 years of experience, Master's degree with 4 years of experience, or PhD with 2 years of experience is required

Required

Demonstrated hand