Automation-Driven Scientist, High-Throughput Synthesis

F. Hoffmann-La Roche AG; Schweiz; Vor Ort; EUR 140.570 - 194.635; Vollzeit

Zusammenfassung

Roche invites a PhD-qualified synthetic organic chemist to join the pRED Small Molecule Research Dolphin team in Basel. The role focuses on automating and scaling synthesis, expanding parallel chemistry and late-stage functionalization, and developing miniaturized, data-driven methods for biological screening.

You will generate high-quality reaction datasets for machine-learning, coordinate cross‑functional and CRO collaborations across Europe and China, and guide digital/automation initiatives

Qualifikationen

• PhD in Synthetic Organic Chemistry with at least four years of industry experience.
• Strong background in automation technology, including solid dosing and liquid handling integrated with analytical and purification methodologies.
• Expertise in synthetic methodology development and hands‑on laboratory experimentation in small‑molecule synthesis.
• Experience assessing and implementing digitalization and automation solutions in chemical laboratories.
• Understanding of machine‑learning concepts for reaction prediction and experience collecting reaction datasets.
• Experience applying parallel medicinal chemistry approaches to solve medicinal chemistry problems.
• Experience in cross‑functional and international relationship building, stakeholder management, and academic collaborations.
• Demonstrated ability to distribute and prioritize work packages between internal and CRO‑based teams.
• Excellent communication and presentation skills, strong interpersonal abilities, and a track record of leading matrix teams without positional authority.

Aufgaben

• Design and run high‑throughput experiments on a miniaturized scale using automation equipment.
• Expand and execute synthetic technologies such as parallel chemistry and late‑stage functionalization.
• Introduce new synthetic methodologies, including reaction miniaturization, photochemical transformations, small‑scale purification, and analytical methodology development.
• Generate high‑quality reaction datasets to support machine‑learning applications.
• Conduct laboratory experiments and complete multi‑step organic synthesis and purification of high‑quality target molecules for biological screening.
• Propose and implement innovative and pragmatic solutions to synthetic and technical problems.
• Collaborate closely with project teams to guide opportunities in late‑stage functionalization, library synthesis, and digital/automation applications.
• Coordinate internal teams and manage CRO teams in Europe and China.
• Serve as a contact point for parallel synthesis between Basel, Shanghai, and San Francisco.

Kenntnisse

Automation tech

Parallel chemistry

Late-stage func

ML datasets

Cross-functional collab

Matrix team leadership

Automation in lab

Analytical purification

Lab digitalization

Ausbildung

PhD in Synthetic Organic Chemistry

Jobbeschreibung

Roche invites a PhD-qualified synthetic organic chemist to join the pRED Small Molecule Research Dolphin team in Basel. The role focuses on automating and scaling synthesis, expanding parallel chemistry and late-stage functionalization, and developing miniaturized, data-driven methods for biological screening.

You will generate high-quality reaction datasets for machine-learning, coordinate cross‑functional and CRO collaborations across Europe and China, and guide digital/automation initiatives