Cell Engineering & Phenotypic Screening Scientist

F. Hoffmann-La Roche AG; Schweiz; Vor Ort; EUR 90.000 - 130.000; Vollzeit

Zusammenfassung

Roche is seeking a highly motivated scientist to drive cellular model development within Small Molecule Research Discovery. You will design and optimize disease-relevant models, deploy CRISPR/Cas editing, and collaborate across automation, data analysis and chemistry teams to advance our drug discovery pipeline.

The role emphasizes hands-on lab work, cross-functional teamwork, and rapid translation of cellular models into screening workflows to accelerate therapeutic candidates.

Qualifikationen

• PhD in cell biology, molecular biology, or closely related scientific discipline.
• Hands-on experience in advanced cell culture techniques, including iPSC differentiation and scalable cell culture.
• Extensive practical experience in CRISPR/Cas-based genome editing, stable cell line generation, clonal isolation, genotyping, and NGS validation.
• Solid experience with cloning, transfection, viral transduction, nucleofection, plasmid/vector design.
• Experience with high-content imaging, assay development, or multiparametric data analysis is a plus.
• Strong English communication and collaborative problem-solving skills.

Aufgaben

• Model Innovation: design, engineer, validate, and optimize disease-relevant cellular models at scale for phenotypic screening.
• Advanced Engineering: apply CRISPR/Cas, vector design, reporter systems, and stable cell lines to build robust assays.
• Pipeline Integration: translate cellular models into scalable workflows for high-content imaging and screening.
• Cross-Functional Collaboration: partner with therapy areas, automation, data analysis, and chemistry teams to interpret results.
• Culture Contribution: foster an inclusive, collaborative and curious team environment.

Jobbeschreibung

Roche is seeking a highly motivated scientist to drive cellular model development within Small Molecule Research Discovery. You will design and optimize disease-relevant models, deploy CRISPR/Cas editing, and collaborate across automation, data analysis and chemistry teams to advance our drug discovery pipeline.

The role emphasizes hands-on lab work, cross-functional teamwork, and rapid translation of cellular models into screening workflows to accelerate therapeutic candidates.