Senior Protein Crystallography Scientist (Remote/Durban)

Placements24; Durban; Hybrid; ZAR 1,500,000 - 2,100,000; Full time

Benefits offered by this job

Health insurance

Retirement provisions

Conference attendance

Remote work option

Job summary

Placements24 is seeking a highly experienced Senior Protein Crystallography Scientist to lead the structural biology program in Durban. You will oversee expression, purification, crystallization, data collection, and structure determination while collaborating with medicinal chemistry and biology teams.

The role requires a PhD with 6+ years of post-doctoral or industry experience, a proven track record of solving high-resolution structures, and proficiency with Phenix/CCP4/Rosetta.

Qualifications

• Ph.D. in Biochemistry, Biophysics, Structural Biology, or a related field.
• Minimum of 6 years of post-doctoral or industry experience in protein crystallography.
• Proven track record of determining multiple high-resolution protein structures.
• Experience with protein expression (e.g., E. coli, insect cells) and purification.
• Expertise in crystallization techniques and data collection/structure refinement.

Responsibilities

• Lead projects focused on structural determination using X-ray crystallography.
• Oversee protein expression, purification, and characterization for crystallization.
• Develop and implement crystallization screening and optimization strategies.
• Collect diffraction data at synchrotron facilities and process to electron density maps.
• Build and refine atomic models of protein structures.
• Interpret structural data in context of SAR and guide lead optimization.
• Mentor junior scientists and contribute to scientific direction.

Skills

Communication skills

Teamwork

Independent work

Leadership

Biochemistry knowledge

Education

PhD in Biochemistry/Biophysics/Structural Biology

Tools

Phenix

CCP4

Rosetta

Job description

Placements24 is seeking a highly experienced Senior Protein Crystallography Scientist to lead the structural biology program in Durban. You will oversee expression, purification, crystallization, data collection, and structure determination while collaborating with medicinal chemistry and biology teams.

The role requires a PhD with 6+ years of post-doctoral or industry experience, a proven track record of solving high-resolution structures, and proficiency with Phenix/CCP4/Rosetta.