Impactful Protein Crystallography Scientist (Hybrid)

Placements24; Sandton; Hybrid; ZAR 1,200,000 - 1,500,000; Full time

Benefits offered by this job

Health insurance

Retirement plan

Conference funding

Hybrid work model

Job summary

Premier Biomedical Research Institute in Sandton, Gauteng, invites a Senior Structural Biologist to advance understanding of protein structures and therapeutics. You will design and execute protein expression, purification, crystallization, and data collection, with hands-on leadership in a hybrid work setting.

The role emphasizes independent research, collaboration with chemists and biologists, and dissemination through publications and conferences.

Qualifications

• PhD in Structural Biology, Biochemistry, Biophysics, or related field.
• 7+ years post-doctoral experience in protein crystallography is preferred.
• Demonstrated expertise in protein expression, purification, and structure determination.
• Proficiency with crystallographic software for data processing, structure solution, and refinement.

Responsibilities

• Design and optimize protocols for expression, purification, and biophysical characterization of target proteins and complexes.
• Develop robust crystallization conditions and perform data collection at synchrotron facilities.
• Determine and refine protein structures using X-ray diffraction data and crystallographic software.
• Collaborate with medicinal chemists and biologists to guide drug design from structural insights.
• Lead and contribute to manuscript preparation and presentations at conferences.

Skills

Protein expression

Protein purification

X-ray crystallography

Data analysis

Scientific communication

Education

PhD in Structural Biology or related field

Tools

Crystallographic software

FPLC systems

SPR/ITC/CD spectroscopy

Job description

Premier Biomedical Research Institute in Sandton, Gauteng, invites a Senior Structural Biologist to advance understanding of protein structures and therapeutics. You will design and execute protein expression, purification, crystallization, and data collection, with hands-on leadership in a hybrid work setting.

The role emphasizes independent research, collaboration with chemists and biologists, and dissemination through publications and conferences.